Guardant Health (GH) 4: Saia John G. bought 974 shares at $0.00 on 2026-10-01; Saia… (Oct 2, 2026)

=== SEC Form 4 — Statement of Changes in Beneficial Ownership === Document Type: 4 Period of Report: 2026-10-01 10b5-1 Pre-arranged Plan: No --- Issuer --- Name: Guardant Health, Inc. (GH) CIK: 0001576280 --- Reporting Owner --- Name: Saia John G. CIK: 0001737840 Role: Officer (Chief Legal Officer) --- Non-Derivative Transactions --- [Transaction #1] Security: Common Stock Date: 2026-10-01 | Code: M (Exercise of derivative) Shares: +974 | Price: $0.00 Shares Owned After: 39,965 | Ownership: D (Direct) [Transaction #2] Security: Common Stock Date: 2026-10-01 | Code: M (Exercise of derivative) Shares: +1,668 | Price: $0.00 Shares Owned After: 41,633 | Ownership: D (Direct) [Transaction #3] Security: Common Stock Date: 2026-10-01 | Code: M (Exercise of derivative) Shares: +2,925 | Price: $0.00 Shares Owned After: 44,558 | Ownership: D (Direct) [Transaction #4] Security: Common Stock Date: 2026-10-01 | Code: M (Exercise of derivative) Shares: +1,496 | Price: $0.00 Shares Owned After: 46,054 | Ownership: D (Direct) [Transaction #5] Security: Common Stock Date: 2026-10-01 | Code: F (Payment of exercise/tax) Shares: -3,706 | Price: $174.75 Total Value: $647,623.50 Shares Owned After: 42,348 | Ownership: D (Direct) Footnotes: [F1] These shares were retained by the Company in order to meet the tax withholding obligations of the award-holder in connection with the vesting of an installment of the restricted stock units. The amount retained by the Company was not in excess of the amount of the tax liability. --- Derivative Transactions --- [Transaction #1] Security: Restricted Stock Units Date: 2026-10-01 | Code: M (Exercise of derivative) Shares: -974 | Price: $0.00 Exercise Price: $0.00 Shares Owned After: 0 | Ownership: D (Direct) Footnotes: [F2] This represents a restricted stock unit award granted on November 7, 2022 that vested over a four-year period. 25% of the shares subject to such award vested on October 1, 2023 and the remaining 75% of the shares vested in equal quarterly installments over the remaining three-year period thereafter. [F3] Not applicable for Restricted Stock Units. [Transaction #2] Security: Restricted Stock Units Date: 2026-10-01 | Code: M (Exercise of derivative) Shares: -1,668 | Price: $0.00 Exercise Price: $0.00 Shares Owned After: 0 | Ownership: D (Direct) Footnotes: [F4] This represents a restricted stock unit award granted on December 13, 2023 that vested over a three-year period. 33% of the shares subject to such award vested on October 1, 2024 and the remaining 67% of the shares vested in equal quarterly installments over the remaining two-year period thereafter. [F3] Not applicable for Restricted Stock Units. [Transaction #3] Security: Restricted Stock Units Date: 2026-10-01 | Code: M (Exercise of derivative) Shares: -2,925 | Price: $0.00 Exercise Price: $0.00 Shares Owned After: 11,701 | Ownership: D (Direct) Footnotes: [F5] This represents a restricted stock unit award granted on November 8, 2024 that vests over a three-year period. 33% of the shares subject to such award vested on October 1, 2025 and the remaining 67% of the shares vests in equal quarterly installments over the remaining two-year period thereafter. [F3] Not applicable for Restricted Stock Units. [Transaction #4] Security: Restricted Stock Units Date: 2026-10-01 | Code: M (Exercise of derivative) Shares: -1,496 | Price: $0.00 Exercise Price: $0.00 Shares Owned After: 8,978 | Ownership: D (Direct) Footnotes: [F6] This represents a restricted stock unit award granted on March 12, 2025 that vests over a three-year period. 33% of the shares subject to such award vested on April 1, 2026 and the remaining 67% of the shares vests in equal quarterly installments over the remaining two-year period thereafter. [F3] Not applicable for Restricted Stock Units. --- Footnotes (Complete Index) --- F1: These shares were retained by the Company in order to meet the tax withholding obligations of the award-holder in connection with the vesting of an installment of the restricted stock units. The amount retained by the Company was not in excess of the amount of the tax liability. F2: This represents a restricted stock unit award granted on November 7, 2022 that vested over a four-year period. 25% of the shares subject to such award vested on October 1, 2023 and the remaining 75% of the shares vested in equal quarterly installments over the remaining three-year period thereafter. F3: Not applicable for Restricted Stock Units. F4: This represents a restricted stock unit award granted on December 13, 2023 that vested over a three-year period. 33% of the shares subject to such award vested on October 1, 2024 and the remaining 67% of the shares vested in equal quarterly installments over the remaining two-year period thereafter. F5: This represents a restricted stock unit award granted on November 8, 2024 that vests over a three-year period. 33% of the shares subject to such award vested on October 1, 2025 and the remaining 67% of the shares vests in equal quarterly installments over the remaining two-year period thereafter. F6: This represents a restricted stock unit award granted on March 12, 2025 that vests over a three-year period. 33% of the shares subject to such award vested on April 1, 2026 and the remaining 67% of the shares vests in equal quarterly installments over the remaining two-year period thereafter. --- Signature --- /s/ /s/ John G. Saia (2026-10-02)