Bio-techne

=== SEC Form 4 — Statement of Changes in Beneficial Ownership === Document Type: 4 Period of Report: 2026-09-28 10b5-1 Pre-arranged Plan: No --- Issuer --- Name: BIO-TECHNE Corp (TECH) CIK: 0000842023 --- Reporting Owner --- Name: HIGGINS JOHN L CIK: 0001208906 Role: Director --- Non-Derivative Transactions --- [Transaction #1] Security: Common Stock Date: 2026-09-28 | Code: M (Exercise of derivative) Shares: +15,940 | Price: $0.00 Shares Owned After: 82,816 | Ownership: D (Direct) [Transaction #2] Security: Common Stock Date: 2026-09-28 | Code: F (Payment of exercise/tax) Shares: -5,562 | Price: $72.51 Total Value: $403,300.62 Shares Owned After: 77,254 | Ownership: D (Direct) --- Derivative Transactions --- [Transaction #1] Security: Stock Options (Right to Buy) Date: 2026-09-28 | Code: M (Exercise of derivative) Shares: -15,940 | Price: $0.00 Exercise Price: $25.30 Exercisable: N/A | Expires: 2026-10-26 Shares Owned After: 0 | Ownership: D (Direct) --- Holdings --- [Holding #1] Security: Stock Options (Right to Buy) Ownership: D (Direct) [Holding #2] Security: Stock Options (Right to Buy) Ownership: D (Direct) [Holding #3] Security: Stock Options (Right to Buy) Ownership: D (Direct) [Holding #4] Security: Stock Options (Right to Buy) Ownership: D (Direct) [Holding #5] Security: Stock Options (Right to Buy) Ownership: D (Direct) [Holding #6] Security: Stock Options (Right to Buy) Ownership: D (Direct) [Holding #7] Security: Stock Options (Right to Buy) Ownership: D (Direct) [Holding #8] Security: Stock Options (Right to Buy) Ownership: D (Direct) [Holding #9] Security: Stock Options (Right to Buy) Ownership: D (Direct) Footnotes: [F1] The option vests on the earlier of the one year anniversary of the grant date (10/30/2025) or the date of Bio-Techne's 2026 annual meeting of shareholders. --- Footnotes (Complete Index) --- F1: The option vests on the earlier of the one year anniversary of the grant date (10/30/2025) or the date of Bio-Techne's 2026 annual meeting of shareholders. --- Signature --- /s/ /s/ Andrew Nick as Attorney-in-Fact for John L. Higgins pursuant to Power of Attorney previously filed (2026-09-30)