Incyte

=== SEC Form 4 — Statement of Changes in Beneficial Ownership === Document Type: 4 Period of Report: 2026-09-22 10b5-1 Pre-arranged Plan: No --- Issuer --- Name: INCYTE CORP (INCY) CIK: 0000879169 --- Reporting Owner --- Name: Gardner David H CIK: 0002085970 Role: Officer (EVP, Chief Strategy Officer) --- Non-Derivative Transactions --- [Transaction #1] Security: Common Stock Date: 2026-09-22 | Code: F (Payment of exercise/tax) Shares: -920 | Price: $126.93 Total Value: $116,775.60 Shares Owned After: 15,904 | Ownership: D (Direct) Footnotes: [F1] Represents shares withheld automatically by the Issuer to satisfy tax withholding obligations due at settlement of restricted stock units previously reported in Table I as common stock. [F2] This includes an aggregate of 14,467 shares of common stock issuable pursuant to previously reported restricted stock units that have not vested. --- Footnotes (Complete Index) --- F1: Represents shares withheld automatically by the Issuer to satisfy tax withholding obligations due at settlement of restricted stock units previously reported in Table I as common stock. F2: This includes an aggregate of 14,467 shares of common stock issuable pursuant to previously reported restricted stock units that have not vested. --- Signature --- /s/ /s/ Elizabeth Feeney, Attorney-In-Fact (2026-09-24)