Guardant Health (GH)

=== SEC Form 4 — Statement of Changes in Beneficial Ownership === Document Type: 4 Period of Report: 2026-09-15 10b5-1 Pre-arranged Plan: Yes --- Issuer --- Name: Guardant Health, Inc. (GH) CIK: 0001576280 --- Reporting Owner --- Name: Tariq Musa CIK: 0001968281 Role: Director --- Non-Derivative Transactions --- [Transaction #1] Security: Common Stock Date: 2026-09-15 | Code: M (Exercise of derivative) Shares: +249 | Price: $0.00 Shares Owned After: 11,565 | Ownership: D (Direct) [Transaction #2] Security: Common Stock Date: 2026-09-16 | Code: S (Open market sale) Shares: -116 | Price: $175.00 Total Value: $20,300.00 Shares Owned After: 11,449 | Ownership: D (Direct) --- Derivative Transactions --- [Transaction #1] Security: Restricted Stock Units Date: 2026-09-15 | Code: M (Exercise of derivative) Shares: -249 | Price: $0.00 Exercise Price: $0.00 Shares Owned After: 1,500 | Ownership: D (Direct) Footnotes: [F1] The restricted stock unit award granted on March 6, 2023 vests over a four-year period. 25% of the shares subject to such award vested on March 15, 2024 and the remaining 75% vests monthly for the three-year period thereafter. [F2] Not applicable for Restricted Stock Units. --- Footnotes (Complete Index) --- F1: The restricted stock unit award granted on March 6, 2023 vests over a four-year period. 25% of the shares subject to such award vested on March 15, 2024 and the remaining 75% vests monthly for the three-year period thereafter. F2: Not applicable for Restricted Stock Units. --- Signature --- /s/ /s/ John G. Saia, as attorney-in-fact for Musa Tariq (2026-09-17)