Guardant Health (GH)

=== SEC Form 4 — Statement of Changes in Beneficial Ownership === Document Type: 4 Period of Report: 2026-09-12 10b5-1 Pre-arranged Plan: No --- Issuer --- Name: Guardant Health, Inc. (GH) CIK: 0001576280 --- Reporting Owner --- Name: Azar Alex M II CIK: 0001402256 Role: Director --- Non-Derivative Transactions --- [Transaction #1] Security: Common Stock Date: 2026-09-12 | Code: M (Exercise of derivative) Shares: +1,651 | Price: $0.00 Shares Owned After: 1,651 | Ownership: D (Direct) --- Derivative Transactions --- [Transaction #1] Security: Restricted Stock Units Date: 2026-09-12 | Code: M (Exercise of derivative) Shares: -1,651 | Price: $0.00 Exercise Price: $0.00 Shares Owned After: 4,953 | Ownership: D (Direct) Footnotes: [F1] The restricted stock unit award was granted on September 12, 2025 and vests over a four-year period. 25% of the shares subject to such award vested on September 12, 2026 and the remaining 75% vests monthly for the three-year period thereafter. [F2] Not applicable for Restricted Stock Units. --- Footnotes (Complete Index) --- F1: The restricted stock unit award was granted on September 12, 2025 and vests over a four-year period. 25% of the shares subject to such award vested on September 12, 2026 and the remaining 75% vests monthly for the three-year period thereafter. F2: Not applicable for Restricted Stock Units. --- Signature --- /s/ /s/ John G. Saia, as attorney-in-fact for Alex M. Azar II (2026-09-14)