Guardant Health (GH)

=== SEC Form 4 — Statement of Changes in Beneficial Ownership === Document Type: 4 Period of Report: 2026-08-21 10b5-1 Pre-arranged Plan: No --- Issuer --- Name: Guardant Health, Inc. (GH) CIK: 0001576280 --- Reporting Owner --- Name: MIGNONE ROBERTO CIK: 0001258394 Role: Director --- Non-Derivative Transactions --- [Transaction #1] Security: Common Stock Date: 2026-08-21 | Code: M (Exercise of derivative) Shares: +264 | Price: $0.00 Shares Owned After: 10,010 | Ownership: D (Direct) --- Derivative Transactions --- [Transaction #1] Security: Restricted Stock Units Date: 2026-08-21 | Code: M (Exercise of derivative) Shares: -264 | Price: $0.00 Exercise Price: $0.00 Shares Owned After: 6,864 | Ownership: D (Direct) Footnotes: [F1] The restricted stock unit award granted on November 8, 2024 vests over a four-year period. 25% of the shares subject to such award vested on October 21, 2025 and the remaining 75% vests monthly for the three-year period thereafter. [F2] Not applicable for Restricted Stock Units. --- Footnotes (Complete Index) --- F1: The restricted stock unit award granted on November 8, 2024 vests over a four-year period. 25% of the shares subject to such award vested on October 21, 2025 and the remaining 75% vests monthly for the three-year period thereafter. F2: Not applicable for Restricted Stock Units. --- Signature --- /s/ /s/ John G. Saia, as attorney-in-fact for Roberto A. Mignone (2026-08-24)