=== SEC Form 4 — Statement of Changes in Beneficial Ownership ===
Document Type: 4
Period of Report: 2026-08-20
10b5-1 Pre-arranged Plan: Yes
--- Issuer ---
Name: THERMO FISHER SCIENTIFIC INC. (TMO)
CIK: 0000097745
--- Reporting Owner ---
Name: CASPER MARC N
CIK: 0001216055
Role: Director, Officer (Chairman & CEO)
--- Non-Derivative Transactions ---
[Transaction #1]
Security: Common Stock
Date: 2026-08-20 | Code: M (Exercise of derivative)
Shares: +10,000 | Price: $309.63
Total Value: $3,096,300.00
Shares Owned After: 133,925.358 | Ownership: D (Direct)
[Transaction #2]
Security: Common Stock
Date: 2026-08-20 | Code: S (Open market sale)
Shares: -909 | Price: $625.45
Total Value: $568,534.05
Shares Owned After: 133,016.358 | Ownership: D (Direct)
Footnotes:
[F1] The transactions reported in this Form 4 were effected pursuant to a Rule 10b5-1 trading plan adopted by the reporting person on April 27, 2026.
[F2] The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $625.00 to $625.80, inclusive. The reporting person undertakes to provide to Thermo Fisher Scientific Inc. ("TMO"), any security holder of TMO or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the ranges set forth in footnotes (2), (3), (4), (5), (6), (7), (8), (9), (10), (11), (12), (13) and (14) to this Form 4.
[Transaction #3]
Security: Common Stock
Date: 2026-08-20 | Code: S (Open market sale)
Shares: -821 | Price: $626.83
Total Value: $514,627.43
Shares Owned After: 132,195.358 | Ownership: D (Direct)
Footnotes:
[F1] The transactions reported in this Form 4 were effected pursuant to a Rule 10b5-1 trading plan adopted by the reporting person on April 27, 2026.
[F3] The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $626.17 to $627.08, inclusive.
[Transaction #4]
Security: Common Stock
Date: 2026-08-20 | Code: S (Open market sale)
Shares: -1,314 | Price: $627.66
Total Value: $824,745.24
Shares Owned After: 130,881.358 | Ownership: D (Direct)
Footnotes:
[F1] The transactions reported in this Form 4 were effected pursuant to a Rule 10b5-1 trading plan adopted by the reporting person on April 27, 2026.
[F4] The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $627.33 to $628.29, inclusive.
[Transaction #5]
Security: Common Stock
Date: 2026-08-20 | Code: S (Open market sale)
Shares: -2,601 | Price: $628.82
Total Value: $1,635,560.82
Shares Owned After: 128,280.358 | Ownership: D (Direct)
Footnotes:
[F1] The transactions reported in this Form 4 were effected pursuant to a Rule 10b5-1 trading plan adopted by the reporting person on April 27, 2026.
[F5] The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $628.36 to $629.33, inclusive.
[Transaction #6]
Security: Common Stock
Date: 2026-08-20 | Code: S (Open market sale)
Shares: -1,250 | Price: $629.85
Total Value: $787,312.50
Shares Owned After: 127,030.358 | Ownership: D (Direct)
Footnotes:
[F1] The transactions reported in this Form 4 were effected pursuant to a Rule 10b5-1 trading plan adopted by the reporting person on April 27, 2026.
[F6] The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $629.41 to $630.37, inclusive.
[Transaction #7]
Security: Common Stock
Date: 2026-08-20 | Code: S (Open market sale)
Shares: -1,035 | Price: $630.87
Total Value: $652,950.45
Shares Owned After: 125,995.358 | Ownership: D (Direct)
Footnotes:
[F1] The transactions reported in this Form 4 were effected pursuant to a Rule 10b5-1 trading plan adopted by the reporting person on April 27, 2026.
[F7] The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $630.47 to $631.37, inclusive.
[Transaction #8]
Security: Common Stock
Date: 2026-08-20 | Code: S (Open market sale)
Shares: -1,430 | Price: $632.01
Total Value: $903,774.30
Shares Owned After: 124,565.358 | Ownership: D (Direct)
Footnotes:
[F1] The transactions reported in this Form 4 were effected pursuant to a Rule 10b5-1 trading plan adopted by the reporting person on April 27, 2026.
[F8] The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $631.52 to $632.44, inclusive.
[Transaction #9]
Security: Common Stock
Date: 2026-08-20 | Code: S (Open market sale)
Shares: -560 | Price: $632.94
Total Value: $354,446.40
Shares Owned After: 124,005.358 | Ownership: D (Direct)
Footnotes:
[F1] The transactions reported in this Form 4 were effected pursuant to a Rule 10b5-1 trading plan adopted by the reporting person on April 27, 2026.
[F9] The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $632.60 to $633.32, inclusive.
[Transaction #10]
Security: Common Stock
Date: 2026-08-20 | Code: S (Open market sale)
Shares: -80 | Price: $633.99
Total Value: $50,719.20
Shares Owned After: 123,925.358 | Ownership: D (Direct)
Footnotes:
[F1] The transactions reported in this Form 4 were effected pursuant to a Rule 10b5-1 trading plan adopted by the reporting person on April 27, 2026.
[Transaction #11]
Security: Common Stock
Date: 2026-08-21 | Code: M (Exercise of derivative)
Shares: +10,000 | Price: $309.63
Total Value: $3,096,300.00
Shares Owned After: 133,925.358 | Ownership: D (Direct)
[Transaction #12]
Security: Common Stock
Date: 2026-08-21 | Code: S (Open market sale)
Shares: -2,727 | Price: $625.46
Total Value: $1,705,629.42
Shares Owned After: 131,198.358 | Ownership: D (Direct)
Footnotes:
[F1] The transactions reported in this Form 4 were effected pursuant to a Rule 10b5-1 trading plan adopted by the reporting person on April 27, 2026.
[F10] The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $625.00 to $625.97, inclusive.
[Transaction #13]
Security: Common Stock
Date: 2026-08-21 | Code: S (Open market sale)
Shares: -3,014 | Price: $626.51
Total Value: $1,888,301.14
Shares Owned After: 128,184.358 | Ownership: D (Direct)
Footnotes:
[F1] The transactions reported in this Form 4 were effected pursuant to a Rule 10b5-1 trading plan adopted by the reporting person on April 27, 2026.
[F11] The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $626.00 to $626.99, inclusive.
[Transaction #14]
Security: Common Stock
Date: 2026-08-21 | Code: S (Open market sale)
Shares: -1,791 | Price: $627.39
Total Value: $1,123,655.49
Shares Owned After: 126,393.358 | Ownership: D (Direct)
Footnotes:
[F1] The transactions reported in this Form 4 were effected pursuant to a Rule 10b5-1 trading plan adopted by the reporting person on April 27, 2026.
[F12] The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $627.00 to $627.99, inclusive.
[Transaction #15]
Security: Common Stock
Date: 2026-08-21 | Code: S (Open market sale)
Shares: -2,147 | Price: $628.61
Total Value: $1,349,625.67
Shares Owned After: 124,246.358 | Ownership: D (Direct)
Footnotes:
[F1] The transactions reported in this Form 4 were effected pursuant to a Rule 10b5-1 trading plan adopted by the reporting person on April 27, 2026.
[F13] The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $628.00 to $628.94, inclusive.
[Transaction #16]
Security: Common Stock
Date: 2026-08-21 | Code: S (Open market sale)
Shares: -321 | Price: $629.10
Total Value: $201,941.10
Shares Owned After: 123,925.358 | Ownership: D (Direct)
Footnotes:
[F1] The transactions reported in this Form 4 were effected pursuant to a Rule 10b5-1 trading plan adopted by the reporting person on April 27, 2026.
[F14] The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $629.00 to $629.20, inclusive.
--- Derivative Transactions ---
[Transaction #1]
Security: Stock Option (Right to Buy)
Date: 2026-08-20 | Code: M (Exercise of derivative)
Shares: -10,000 | Price: $0.00
Exercise Price: $309.63
Exercisable: N/A | Expires: 2027-02-25
Shares Owned After: 10,275 | Ownership: D (Direct)
Footnotes:
[F16] The option vested in four equal installments on February 25, 2021, 2022, 2023, and 2024.
[Transaction #2]
Security: Stock Option (Right to Buy)
Date: 2026-08-21 | Code: M (Exercise of derivative)
Shares: -10,000 | Price: $0.00
Exercise Price: $309.63
Exercisable: N/A | Expires: 2027-02-25
Shares Owned After: 275 | Ownership: D (Direct)
Footnotes:
[F16] The option vested in four equal installments on February 25, 2021, 2022, 2023, and 2024.
--- Holdings ---
[Holding #1]
Security: Common Stock
Ownership: I (Indirect)
Footnotes:
[F15] The reporting person disclaims beneficial ownership of the securities reported herein as indirectly beneficially owned, except to the extent of any pecuniary interest therein.
[Holding #2]
Security: Common Stock
Ownership: I (Indirect)
Footnotes:
[F15] The reporting person disclaims beneficial ownership of the securities reported herein as indirectly beneficially owned, except to the extent of any pecuniary interest therein.
--- Footnotes (Complete Index) ---
F1: The transactions reported in this Form 4 were effected pursuant to a Rule 10b5-1 trading plan adopted by the reporting person on April 27, 2026.
F10: The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $625.00 to $625.97, inclusive.
F11: The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $626.00 to $626.99, inclusive.
F12: The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $627.00 to $627.99, inclusive.
F13: The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $628.00 to $628.94, inclusive.
F14: The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $629.00 to $629.20, inclusive.
F15: The reporting person disclaims beneficial ownership of the securities reported herein as indirectly beneficially owned, except to the extent of any pecuniary interest therein.
F16: The option vested in four equal installments on February 25, 2021, 2022, 2023, and 2024.
F2: The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $625.00 to $625.80, inclusive. The reporting person undertakes to provide to Thermo Fisher Scientific Inc. ("TMO"), any security holder of TMO or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the ranges set forth in footnotes (2), (3), (4), (5), (6), (7), (8), (9), (10), (11), (12), (13) and (14) to this Form 4.
F3: The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $626.17 to $627.08, inclusive.
F4: The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $627.33 to $628.29, inclusive.
F5: The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $628.36 to $629.33, inclusive.
F6: The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $629.41 to $630.37, inclusive.
F7: The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $630.47 to $631.37, inclusive.
F8: The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $631.52 to $632.44, inclusive.
F9: The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $632.60 to $633.32, inclusive.
--- Signature ---
/s/ /s/ Melodie T. Morin, Attorney-in-Fact for Marc N. Casper (2026-08-24)
