Bio-techne

=== SEC Form 4 — Statement of Changes in Beneficial Ownership === Document Type: 4 Period of Report: 2026-08-17 10b5-1 Pre-arranged Plan: No --- Issuer --- Name: BIO-TECHNE Corp (TECH) CIK: 0000842023 --- Reporting Owner --- Name: Crouse Steven C. CIK: 0002065241 Role: Officer (President - Diag & Spatial Bi) --- Derivative Transactions --- [Transaction #1] Security: Restricted Stock Units Date: 2026-08-17 | Code: A (Grant or award) Shares: +8,702 | Price: $0.00 Shares Owned After: 8,702 | Ownership: D (Direct) Footnotes: [F8] Each restricted stock unit represents a contingent right to receive one share of Bio-Techne common stock. [F15] 2,901 restricted stock units vest on each of 8/17/2027 and 8/17/2028, and 2,900 restricted stock units vest on 8/17/2029. [F15] 2,901 restricted stock units vest on each of 8/17/2027 and 8/17/2028, and 2,900 restricted stock units vest on 8/17/2029. [Transaction #2] Security: Restricted Stock Units Date: 2026-08-17 | Code: A (Grant or award) Shares: +14,140 | Price: $0.00 Shares Owned After: 14,140 | Ownership: D (Direct) Footnotes: [F8] Each restricted stock unit represents a contingent right to receive one share of Bio-Techne common stock. [F16] 14,140 restricted stock units vest on 8/17/2029. [F16] 14,140 restricted stock units vest on 8/17/2029. --- Holdings --- [Holding #1] Security: Common Stock Ownership: D (Direct) [Holding #2] Security: Stock Option (right to buy) Ownership: D (Direct) Footnotes: [F1] 100% vested. [Holding #3] Security: Stock Option (right to buy) Ownership: D (Direct) Footnotes: [F1] 100% vested. [Holding #4] Security: Stock Option (right to buy) Ownership: D (Direct) Footnotes: [F1] 100% vested. [Holding #5] Security: Stock Option (right to buy) Ownership: D (Direct) Footnotes: [F2] Options to purchase 3,162 shares vest on each of 8/15/2024, 8/15/2026 and 8/15/2027; and options to purchase 3,163 shares vest on 8/15/2025. [Holding #6] Security: Stock Option (right to buy) Ownership: D (Direct) Footnotes: [F3] Options to purchase 1,832 shares vest on each of 5/1/2025, 5/1/2026 and 5/1/2028; and options to purchase 1,831 shares vest on 5/1/2027. [Holding #7] Security: Stock Option (right to buy) Ownership: D (Direct) Footnotes: [F4] Options to purchase 4,283 shares vest on each of 8/15/2025, 8/15/2027 and 8/15/2028; and options to purchase 4,284 shares vest on 8/15/2026. [Holding #8] Security: Stock Option (right to buy) Ownership: D (Direct) Footnotes: [F5] Options to purchase 1,359 shares vest on each of 6/2/2026 and 6/2/2028; and options to purchase 1,358 shares vest on each of 6/2/2027 and 6/2/2029. [Holding #9] Security: Stock Option (right to buy) Ownership: D (Direct) Footnotes: [F6] Options to purchase 4,788 shares vest on each of 8/15/2026, 8/15/2027 and 8/15/2029; and options to purchase 4,787 shares vest on 8/15/2028. [Holding #10] Security: Stock Option (right to buy) Ownership: D (Direct) Footnotes: [F7] Options to purchase 478 shares vest on each of 3/2/2027, 3/2/2028 and 3/2/2030; and options to purchase 477 shares vest on 3/2/2029. [Holding #11] Security: Performance Restricted Stock Units Ownership: D (Direct) Footnotes: [F8] Each restricted stock unit represents a contingent right to receive one share of Bio-Techne common stock. [F9] Vests in full or in part on 8/15/2028 if certain performance goals are achieved (or such later date as performance is certified by the Administrator). [F9] Vests in full or in part on 8/15/2028 if certain performance goals are achieved (or such later date as performance is certified by the Administrator). [Holding #12] Security: Restricted Stock Units Ownership: D (Direct) Footnotes: [F8] Each restricted stock unit represents a contingent right to receive one share of Bio-Techne common stock. [F10] 794 restricted stock units vest on 5/1/2027. [F10] 794 restricted stock units vest on 5/1/2027. [Holding #13] Security: Restricted Stock Units Ownership: D (Direct) Footnotes: [F8] Each restricted stock unit represents a contingent right to receive one share of Bio-Techne common stock. [F11] 600 restricted stock units vest on each of 6/2/2027 and 6/2/2028. [F11] 600 restricted stock units vest on each of 6/2/2027 and 6/2/2028. [Holding #14] Security: Restricted Stock Units Ownership: D (Direct) Footnotes: [F8] Each restricted stock unit represents a contingent right to receive one share of Bio-Techne common stock. [F12] 1,869 restricted stock units vest on 8/15/2027. [F12] 1,869 restricted stock units vest on 8/15/2027. [Holding #15] Security: Restricted Stock Units Ownership: D (Direct) Footnotes: [F8] Each restricted stock unit represents a contingent right to receive one share of Bio-Techne common stock. [F13] 2,177 restricted stock units vest on 8/15/2027, and 2,176 restricted stock units vest on 8/15/2028. [F13] 2,177 restricted stock units vest on 8/15/2027, and 2,176 restricted stock units vest on 8/15/2028. [Holding #16] Security: Restricted Stock Units Ownership: D (Direct) Footnotes: [F8] Each restricted stock unit represents a contingent right to receive one share of Bio-Techne common stock. [F14] 245 restricted stock units vest on each of 3/2/2027, 3/2/2028 and 3/2/2029. [F14] 245 restricted stock units vest on each of 3/2/2027, 3/2/2028 and 3/2/2029. --- Footnotes (Complete Index) --- F1: 100% vested. F10: 794 restricted stock units vest on 5/1/2027. F11: 600 restricted stock units vest on each of 6/2/2027 and 6/2/2028. F12: 1,869 restricted stock units vest on 8/15/2027. F13: 2,177 restricted stock units vest on 8/15/2027, and 2,176 restricted stock units vest on 8/15/2028. F14: 245 restricted stock units vest on each of 3/2/2027, 3/2/2028 and 3/2/2029. F15: 2,901 restricted stock units vest on each of 8/17/2027 and 8/17/2028, and 2,900 restricted stock units vest on 8/17/2029. F16: 14,140 restricted stock units vest on 8/17/2029. F2: Options to purchase 3,162 shares vest on each of 8/15/2024, 8/15/2026 and 8/15/2027; and options to purchase 3,163 shares vest on 8/15/2025. F3: Options to purchase 1,832 shares vest on each of 5/1/2025, 5/1/2026 and 5/1/2028; and options to purchase 1,831 shares vest on 5/1/2027. F4: Options to purchase 4,283 shares vest on each of 8/15/2025, 8/15/2027 and 8/15/2028; and options to purchase 4,284 shares vest on 8/15/2026. F5: Options to purchase 1,359 shares vest on each of 6/2/2026 and 6/2/2028; and options to purchase 1,358 shares vest on each of 6/2/2027 and 6/2/2029. F6: Options to purchase 4,788 shares vest on each of 8/15/2026, 8/15/2027 and 8/15/2029; and options to purchase 4,787 shares vest on 8/15/2028. F7: Options to purchase 478 shares vest on each of 3/2/2027, 3/2/2028 and 3/2/2030; and options to purchase 477 shares vest on 3/2/2029. F8: Each restricted stock unit represents a contingent right to receive one share of Bio-Techne common stock. F9: Vests in full or in part on 8/15/2028 if certain performance goals are achieved (or such later date as performance is certified by the Administrator). --- Signature --- /s/ /s/ Andrew Nick as Attorney-in-Fact for Steven C. Crouse pursuant to Power of Attorney previously filed. (2026-08-19)