Bio-techne

=== SEC Form 4 — Statement of Changes in Beneficial Ownership === Document Type: 4 Period of Report: 2026-08-17 10b5-1 Pre-arranged Plan: No --- Issuer --- Name: BIO-TECHNE Corp (TECH) CIK: 0000842023 --- Reporting Owner --- Name: Herr Amy E. CIK: 0002055523 Role: Director --- Derivative Transactions --- [Transaction #1] Security: Restricted Stock Units Date: 2026-08-17 | Code: A (Grant or award) Shares: +1,381 | Price: $0.00 Shares Owned After: 1,381 | Ownership: I (Indirect) | Nature: By significant other Footnotes: [F7] Each restricted stock unit represents a contingent right to receive one share of Bio-Techne common stock. [F11] 460 restricted stock units vest on each of 8/17/2027 and 8/17/2028, and 461 restricted stock units vest on 8/17/2029. [F11] 460 restricted stock units vest on each of 8/17/2027 and 8/17/2028, and 461 restricted stock units vest on 8/17/2029. --- Holdings --- [Holding #1] Security: Common Stock Ownership: D (Direct) [Holding #2] Security: Common Stock Ownership: I (Indirect) [Holding #3] Security: Stock Option (Right to Buy) Ownership: I (Indirect) Footnotes: [F1] Fully vested. [Holding #4] Security: Stock Option (Right to Buy) Ownership: I (Indirect) Footnotes: [F1] Fully vested. [Holding #5] Security: Stock Option (Right to Buy) Ownership: I (Indirect) Footnotes: [F1] Fully vested. [Holding #6] Security: Stock Option (Right to Buy) Ownership: I (Indirect) Footnotes: [F2] Options to purchase 271 shares vest on each of 8/15/2024, 8/15/2025, 8/15/2026 and 8/15/2027. [Holding #7] Security: Stock Option (Right to Buy) Ownership: I (Indirect) Footnotes: [F3] Options to purchase 367 shares vest on each of 8/15/2025, 8/15/2026, 8/15/2027 and 8/15/2028. [Holding #8] Security: Stock Option (Right to Buy) Ownership: D (Direct) Footnotes: [F1] Fully vested. [Holding #9] Security: Stock Option (Right to Buy) Ownership: I (Indirect) Footnotes: [F4] Options to purchase 86 shares vest on each of 2/3/2026, 2/3/2027, 2/3/2028 and 2/3/2029. [Holding #10] Security: Stock Option (Right to Buy) Ownership: I (Indirect) Footnotes: [F5] Options to purchase 912 shares vest on each of 8/15/2026 and 8/15/2027, and options to purchase 911 shares vest on 8/15/2028. [Holding #11] Security: Stock Option (Right to Buy) Ownership: D (Direct) Footnotes: [F6] This option vests on the earlier of the one year anniversary of the grant date (10/30/2025) or the date of Bio-Techne's 2026 annual meeting of shareholders. [Holding #12] Security: Restricted Stock Units Ownership: I (Indirect) Footnotes: [F7] Each restricted stock unit represents a contingent right to receive one share of Bio-Techne common stock. [F8] 160 restricted stock units vest on 8/15/2027. [F8] 160 restricted stock units vest on 8/15/2027. [Holding #13] Security: Restricted Stock Units Ownership: I (Indirect) Footnotes: [F7] Each restricted stock unit represents a contingent right to receive one share of Bio-Techne common stock. [F9] 38 restricted stock units vest on 2/3/2027, and 39 restricted stock units vest on 2/3/2028. [F9] 38 restricted stock units vest on 2/3/2027, and 39 restricted stock units vest on 2/3/2028. [Holding #14] Security: Restricted Stock Units Ownership: I (Indirect) Footnotes: [F7] Each restricted stock unit represents a contingent right to receive one share of Bio-Techne common stock. [F10] 311 restricted stock units vest on each of 8/15/2026 and 8/15/2027, and 310 restricted stock units vest on 8/15/2028. [F10] 311 restricted stock units vest on each of 8/15/2026 and 8/15/2027, and 310 restricted stock units vest on 8/15/2028. --- Footnotes (Complete Index) --- F1: Fully vested. F10: 311 restricted stock units vest on each of 8/15/2026 and 8/15/2027, and 310 restricted stock units vest on 8/15/2028. F11: 460 restricted stock units vest on each of 8/17/2027 and 8/17/2028, and 461 restricted stock units vest on 8/17/2029. F2: Options to purchase 271 shares vest on each of 8/15/2024, 8/15/2025, 8/15/2026 and 8/15/2027. F3: Options to purchase 367 shares vest on each of 8/15/2025, 8/15/2026, 8/15/2027 and 8/15/2028. F4: Options to purchase 86 shares vest on each of 2/3/2026, 2/3/2027, 2/3/2028 and 2/3/2029. F5: Options to purchase 912 shares vest on each of 8/15/2026 and 8/15/2027, and options to purchase 911 shares vest on 8/15/2028. F6: This option vests on the earlier of the one year anniversary of the grant date (10/30/2025) or the date of Bio-Techne's 2026 annual meeting of shareholders. F7: Each restricted stock unit represents a contingent right to receive one share of Bio-Techne common stock. F8: 160 restricted stock units vest on 8/15/2027. F9: 38 restricted stock units vest on 2/3/2027, and 39 restricted stock units vest on 2/3/2028. --- Signature --- /s/ /s/ Andrew Nick as Attorney-in-Fact for Amy E. Herr pursuant to Power of Attorney previously filed (2026-08-19)