Bio-techne

=== SEC Form 4 — Statement of Changes in Beneficial Ownership === Document Type: 4 Period of Report: 2026-08-17 10b5-1 Pre-arranged Plan: No --- Issuer --- Name: BIO-TECHNE Corp (TECH) CIK: 0000842023 --- Reporting Owner --- Name: Kelderman Kim CIK: 0001739054 Role: Director, Officer (Chief Executive Officer) --- Derivative Transactions --- [Transaction #1] Security: Restricted Stock Units Date: 2026-08-17 | Code: A (Grant or award) Shares: +57,590 | Price: $0.00 Shares Owned After: 57,590 | Ownership: D (Direct) Footnotes: [F7] Each restricted stock unit represents a contingent right to receive one share of Bio-Techne common stock. [F12] 19,197 restricted stock units vest on each of 8/17/2027 and 8/17/2028, and 19,196 restricted stock units vest on 8/17/2029. [F12] 19,197 restricted stock units vest on each of 8/17/2027 and 8/17/2028, and 19,196 restricted stock units vest on 8/17/2029. [Transaction #2] Security: Restricted Stock Units Date: 2026-08-17 | Code: A (Grant or award) Shares: +93,582 | Price: $0.00 Shares Owned After: 93,582 | Ownership: D (Direct) Footnotes: [F7] Each restricted stock unit represents a contingent right to receive one share of Bio-Techne common stock. [F13] 93,582 restricted stock units vest on 8/17/2029. [F13] 93,582 restricted stock units vest on 8/17/2029. --- Holdings --- [Holding #1] Security: Common Stock Ownership: D (Direct) [Holding #2] Security: Stock Option (Right to Buy) Ownership: D (Direct) Footnotes: [F1] Fully exercisable. [Holding #3] Security: Stock Option (Right to Buy) Ownership: D (Direct) Footnotes: [F1] Fully exercisable. [Holding #4] Security: Stock Options (Right to Buy) Ownership: D (Direct) Footnotes: [F1] Fully exercisable. [Holding #5] Security: Stock Options (Right to Buy) Ownership: D (Direct) Footnotes: [F1] Fully exercisable. [Holding #6] Security: Stock Options (Right to Buy) Ownership: D (Direct) Footnotes: [F2] Options to purchase 7,348 shares vest on each of 8/15/2024, 8/15/2025 and 8/15/2027 and options to purchase 7,347 shares vest on 8/15/2026. [Holding #7] Security: Stock Options (Right to Buy) Ownership: D (Direct) Footnotes: [F3] Options to purchase 9,563 shares vest on each of 11/1/2024, 11/1/2025, 11/1/2026 and 11/1/2027. [Holding #8] Security: Stock Options (Right to Buy) Ownership: D (Direct) Footnotes: [F1] Fully exercisable. [Holding #9] Security: Stock Options (Right to Buy) Ownership: D (Direct) Footnotes: [F4] Options to purchase 12,973 shares vest on each of 2/1/2025 and 2/1/2027, and options to purchase 12,972 shares vest on each of 2/1/2026 and 2/1/2028. [Holding #10] Security: Stock Options (Right to Buy) Ownership: D (Direct) Footnotes: [F5] Options to purchase 17,265 shares vest on each of 8/15/2025, 8/15/2026 and 8/15/2027, and options to purchase 17,266 shares vest on 8/15/2028. [Holding #11] Security: Stock Options (Right to Buy) Ownership: D (Direct) Footnotes: [F6] Options to purchase 30,147 shares vest on each of 8/15/2026, 8/15/2027 and 8/15/2028. [Holding #12] Security: Performance Restricted Stock Units Ownership: D (Direct) Footnotes: [F7] Each restricted stock unit represents a contingent right to receive one share of Bio-Techne common stock. [F8] Vests in full or in part on 8/15/2027 if certain performance goals are achieved (or such later date as performance is certified by the Administrator). [F8] Vests in full or in part on 8/15/2027 if certain performance goals are achieved (or such later date as performance is certified by the Administrator). [Holding #13] Security: Performance Restricted Stock Units Ownership: D (Direct) Footnotes: [F7] Each restricted stock unit represents a contingent right to receive one share of Bio-Techne common stock. [F9] Vests in full or in part on 8/15/2028 if certain performance goals are achieved (or such later date as performance is certified by the Administrator). [F9] Vests in full or in part on 8/15/2028 if certain performance goals are achieved (or such later date as performance is certified by the Administrator). [Holding #14] Security: Restricted Stock Units Ownership: D (Direct) Footnotes: [F7] Each restricted stock unit represents a contingent right to receive one share of Bio-Techne common stock. [F10] 8,544 restricted stock units vest on 8/15/2027. [F10] 8,544 restricted stock units vest on 8/15/2027. [Holding #15] Security: Restricted Stock Units Ownership: D (Direct) Footnotes: [F7] Each restricted stock unit represents a contingent right to receive one share of Bio-Techne common stock. [F11] 11,785 restricted stock units vest on 8/15/2027, and 11,784 restricted stock units vest on 8/15/2028. [F11] 11,785 restricted stock units vest on 8/15/2027, and 11,784 restricted stock units vest on 8/15/2028. --- Footnotes (Complete Index) --- F1: Fully exercisable. F10: 8,544 restricted stock units vest on 8/15/2027. F11: 11,785 restricted stock units vest on 8/15/2027, and 11,784 restricted stock units vest on 8/15/2028. F12: 19,197 restricted stock units vest on each of 8/17/2027 and 8/17/2028, and 19,196 restricted stock units vest on 8/17/2029. F13: 93,582 restricted stock units vest on 8/17/2029. F2: Options to purchase 7,348 shares vest on each of 8/15/2024, 8/15/2025 and 8/15/2027 and options to purchase 7,347 shares vest on 8/15/2026. F3: Options to purchase 9,563 shares vest on each of 11/1/2024, 11/1/2025, 11/1/2026 and 11/1/2027. F4: Options to purchase 12,973 shares vest on each of 2/1/2025 and 2/1/2027, and options to purchase 12,972 shares vest on each of 2/1/2026 and 2/1/2028. F5: Options to purchase 17,265 shares vest on each of 8/15/2025, 8/15/2026 and 8/15/2027, and options to purchase 17,266 shares vest on 8/15/2028. F6: Options to purchase 30,147 shares vest on each of 8/15/2026, 8/15/2027 and 8/15/2028. F7: Each restricted stock unit represents a contingent right to receive one share of Bio-Techne common stock. F8: Vests in full or in part on 8/15/2027 if certain performance goals are achieved (or such later date as performance is certified by the Administrator). F9: Vests in full or in part on 8/15/2028 if certain performance goals are achieved (or such later date as performance is certified by the Administrator). --- Signature --- /s/ /s/ Andrew Nick, Attorney-in-Fact for Kim Kelderman pursuant to Power of Attorney previously filed. (2026-08-19)