Charles River (CRL)

=== SEC Form 4 — Statement of Changes in Beneficial Ownership === Document Type: 4 Period of Report: 2026-08-06 10b5-1 Pre-arranged Plan: No --- Issuer --- Name: CHARLES RIVER LABORATORIES INTERNATIONAL, INC. (CRL) CIK: 0001100682 --- Reporting Owner --- Name: Knell Michael Gunnar CIK: 0001543779 Role: Officer (SVP, Finance and CAO) --- Non-Derivative Transactions --- [Transaction #1] Security: Common Stock Date: 2026-08-06 | Code: S (Open market sale) Shares: -1,274 | Price: $259.07 Total Value: $330,055.18 Shares Owned After: 14,878 | Ownership: D (Direct) Footnotes: [F1] This transaction was executed in multiple trades at prices ranging from $258.77 to $259.43. The price reported above reflects the weighted average sale price. The reporting person hereby undertakes to provide upon request to the SEC staff, the issuer or a security holder of the issuer full information regarding the number of shares and prices at which the transaction was effected. [Transaction #2] Security: Common Stock Date: 2026-08-06 | Code: S (Open market sale) Shares: -901 | Price: $260.63 Total Value: $234,827.63 Shares Owned After: 13,977 | Ownership: D (Direct) Footnotes: [F2] This transaction was executed in multiple trades at prices ranging from $259.97 to $260.94. The price reported above reflects the weighted average sale price. The reporting person hereby undertakes to provide upon request to the SEC staff, the issuer or a security holder of the issuer full information regarding the number of shares and prices at which the transaction was effected. [Transaction #3] Security: Common Stock Date: 2026-08-06 | Code: S (Open market sale) Shares: -810 | Price: $261.45 Total Value: $211,774.50 Shares Owned After: 13,167 | Ownership: D (Direct) Footnotes: [F3] This transaction was executed in multiple trades at prices ranging from $261.00 to $261.84. The price reported above reflects the weighted average sale price. The reporting person hereby undertakes to provide upon request to the SEC staff, the issuer or a security holder of the issuer full information regarding the number of shares and prices at which the transaction was effected. [Transaction #4] Security: Common Stock Date: 2026-08-06 | Code: S (Open market sale) Shares: -213 | Price: $262.37 Total Value: $55,884.81 Shares Owned After: 12,954 | Ownership: D (Direct) Footnotes: [F4] This transaction was executed in multiple trades at prices ranging from $262.26 to $262.50. The price reported above reflects the weighted average sale price. The reporting person hereby undertakes to provide upon request to the SEC staff, the issuer or a security holder of the issuer full information regarding the number of shares and prices at which the transaction was effected. [Transaction #5] Security: Common Stock Date: 2026-08-06 | Code: S (Open market sale) Shares: -620 | Price: $263.94 Total Value: $163,642.80 Shares Owned After: 12,334 | Ownership: D (Direct) Footnotes: [F5] This transaction was executed in multiple trades at prices ranging from $263.39 to $264.29. The price reported above reflects the weighted average sale price. The reporting person hereby undertakes to provide upon request to the SEC staff, the issuer or a security holder of the issuer full information regarding the number of shares and prices at which the transaction was effected. [Transaction #6] Security: Common Stock Date: 2026-08-06 | Code: S (Open market sale) Shares: -482 | Price: $265.17 Total Value: $127,811.94 Shares Owned After: 11,852 | Ownership: D (Direct) Footnotes: [F6] This transaction was executed in multiple trades at prices ranging from $264.91 to $265.60. The price reported above reflects the weighted average sale price. The reporting person hereby undertakes to provide upon request to the SEC staff, the issuer or a security holder of the issuer full information regarding the number of shares and prices at which the transaction was effected. [Transaction #7] Security: Common Stock Date: 2026-08-06 | Code: M (Exercise of derivative) Shares: +404 | Price: $179.66 Total Value: $72,582.64 Shares Owned After: 12,256 | Ownership: D (Direct) [Transaction #8] Security: Common Stock Date: 2026-08-06 | Code: M (Exercise of derivative) Shares: +1,205 | Price: $194.12 Total Value: $233,914.60 Shares Owned After: 13,461 | Ownership: D (Direct) [Transaction #9] Security: Common Stock Date: 2026-08-06 | Code: M (Exercise of derivative) Shares: +736 | Price: $208.44 Total Value: $153,411.84 Shares Owned After: 14,197 | Ownership: D (Direct) [Transaction #10] Security: Common Stock Date: 2026-08-06 | Code: S (Open market sale) Shares: -404 | Price: $258.53 Total Value: $104,446.12 Shares Owned After: 13,793 | Ownership: D (Direct) [Transaction #11] Security: Common Stock Date: 2026-08-06 | Code: S (Open market sale) Shares: -1,205 | Price: $258.53 Total Value: $311,528.65 Shares Owned After: 12,588 | Ownership: D (Direct) [Transaction #12] Security: Common Stock Date: 2026-08-06 | Code: S (Open market sale) Shares: -736 | Price: $258.53 Total Value: $190,278.08 Shares Owned After: 11,852 | Ownership: D (Direct) --- Derivative Transactions --- [Transaction #1] Security: Stock Options (Right to Buy) Date: 2026-08-06 | Code: M (Exercise of derivative) Shares: -404 | Price: $0.00 Exercisable: N/A | Expires: 2030-05-29 Shares Owned After: 0 | Ownership: D (Direct) [Transaction #2] Security: Stock Options (Right to Buy) Date: 2026-08-06 | Code: M (Exercise of derivative) Shares: -1,205 | Price: $0.00 Exercisable: N/A | Expires: 2033-05-26 Shares Owned After: 402 | Ownership: D (Direct) [Transaction #3] Security: Stock Options (Right to Buy) Date: 2026-08-06 | Code: M (Exercise of derivative) Shares: -736 | Price: $0.00 Exercisable: N/A | Expires: 2034-05-31 Shares Owned After: 736 | Ownership: D (Direct) --- Footnotes (Complete Index) --- F1: This transaction was executed in multiple trades at prices ranging from $258.77 to $259.43. The price reported above reflects the weighted average sale price. The reporting person hereby undertakes to provide upon request to the SEC staff, the issuer or a security holder of the issuer full information regarding the number of shares and prices at which the transaction was effected. F2: This transaction was executed in multiple trades at prices ranging from $259.97 to $260.94. The price reported above reflects the weighted average sale price. The reporting person hereby undertakes to provide upon request to the SEC staff, the issuer or a security holder of the issuer full information regarding the number of shares and prices at which the transaction was effected. F3: This transaction was executed in multiple trades at prices ranging from $261.00 to $261.84. The price reported above reflects the weighted average sale price. The reporting person hereby undertakes to provide upon request to the SEC staff, the issuer or a security holder of the issuer full information regarding the number of shares and prices at which the transaction was effected. F4: This transaction was executed in multiple trades at prices ranging from $262.26 to $262.50. The price reported above reflects the weighted average sale price. The reporting person hereby undertakes to provide upon request to the SEC staff, the issuer or a security holder of the issuer full information regarding the number of shares and prices at which the transaction was effected. F5: This transaction was executed in multiple trades at prices ranging from $263.39 to $264.29. The price reported above reflects the weighted average sale price. The reporting person hereby undertakes to provide upon request to the SEC staff, the issuer or a security holder of the issuer full information regarding the number of shares and prices at which the transaction was effected. F6: This transaction was executed in multiple trades at prices ranging from $264.91 to $265.60. The price reported above reflects the weighted average sale price. The reporting person hereby undertakes to provide upon request to the SEC staff, the issuer or a security holder of the issuer full information regarding the number of shares and prices at which the transaction was effected. --- Signature --- /s/ /s/ Michael G. Knell (2026-08-10)