INCYTE CORP (INCY) · Insider Trading (Form 4) SEC Filing

=== SEC Form 4 — Statement of Changes in Beneficial Ownership === Document Type: 4 Period of Report: 2026-07-31 10b5-1 Pre-arranged Plan: Yes --- Issuer --- Name: INCYTE CORP (INCY) CIK: 0000879169 --- Reporting Owner --- Name: Mayes Patrick A CIK: 0002079962 Role: Officer (EVP & Chief Scientific Officer) --- Non-Derivative Transactions --- [Transaction #1] Security: Common Stock Date: 2026-07-31 | Code: M (Exercise of derivative) Shares: +2,918 | Price: $61.18 Total Value: $178,523.24 Shares Owned After: 66,546 | Ownership: D (Direct) [Transaction #2] Security: Common Stock Date: 2026-07-31 | Code: M (Exercise of derivative) Shares: +2,284 | Price: $64.25 Total Value: $146,747.00 Shares Owned After: 68,830 | Ownership: D (Direct) [Transaction #3] Security: Common Stock Date: 2026-07-31 | Code: M (Exercise of derivative) Shares: +2,709 | Price: $61.76 Total Value: $167,307.84 Shares Owned After: 71,539 | Ownership: D (Direct) [Transaction #4] Security: Common Stock Date: 2026-07-31 | Code: M (Exercise of derivative) Shares: +3,148 | Price: $68.62 Total Value: $216,015.76 Shares Owned After: 74,687 | Ownership: D (Direct) [Transaction #5] Security: Common Stock Date: 2026-07-31 | Code: M (Exercise of derivative) Shares: +2,072 | Price: $71.93 Total Value: $149,038.96 Shares Owned After: 76,759 | Ownership: D (Direct) [Transaction #6] Security: Common Stock Date: 2026-07-31 | Code: M (Exercise of derivative) Shares: +9,459 | Price: $72.27 Total Value: $683,601.93 Shares Owned After: 86,218 | Ownership: D (Direct) [Transaction #7] Security: Common Stock Date: 2026-07-31 | Code: M (Exercise of derivative) Shares: +2,623 | Price: $74.78 Total Value: $196,147.94 Shares Owned After: 88,841 | Ownership: D (Direct) [Transaction #8] Security: Common Stock Date: 2026-07-31 | Code: M (Exercise of derivative) Shares: +2,864 | Price: $77.67 Total Value: $222,446.88 Shares Owned After: 91,705 | Ownership: D (Direct) [Transaction #9] Security: Common Stock Date: 2026-07-31 | Code: M (Exercise of derivative) Shares: +1,643 | Price: $80.50 Total Value: $132,261.50 Shares Owned After: 93,348 | Ownership: D (Direct) [Transaction #10] Security: Common Stock Date: 2026-07-31 | Code: M (Exercise of derivative) Shares: +3,023 | Price: $83.20 Total Value: $251,513.60 Shares Owned After: 96,371 | Ownership: D (Direct) [Transaction #11] Security: Common Stock Date: 2026-07-31 | Code: M (Exercise of derivative) Shares: +2,623 | Price: $83.58 Total Value: $219,230.34 Shares Owned After: 98,994 | Ownership: D (Direct) [Transaction #12] Security: Common Stock Date: 2026-07-31 | Code: M (Exercise of derivative) Shares: +1,642 | Price: $85.01 Total Value: $139,586.42 Shares Owned After: 100,636 | Ownership: D (Direct) [Transaction #13] Security: Common Stock Date: 2026-07-31 | Code: M (Exercise of derivative) Shares: +2,293 | Price: $90.56 Total Value: $207,654.08 Shares Owned After: 102,929 | Ownership: D (Direct) [Transaction #14] Security: Common Stock Date: 2026-07-31 | Code: M (Exercise of derivative) Shares: +85 | Price: $106.47 Total Value: $9,049.95 Shares Owned After: 103,014 | Ownership: D (Direct) [Transaction #15] Security: Common Stock Date: 2026-07-31 | Code: M (Exercise of derivative) Shares: +326 | Price: $105.43 Total Value: $34,370.18 Shares Owned After: 103,340 | Ownership: D (Direct) [Transaction #16] Security: Common Stock Date: 2026-07-31 | Code: S (Open market sale) Shares: -14,661 | Price: $119.46 Total Value: $1,751,403.06 Shares Owned After: 88,679 | Ownership: D (Direct) [Transaction #17] Security: Common Stock Date: 2026-07-31 | Code: S (Open market sale) Shares: -5,332 | Price: $119.42 Total Value: $636,747.44 Shares Owned After: 83,347 | Ownership: D (Direct) [Transaction #18] Security: Common Stock Date: 2026-07-31 | Code: S (Open market sale) Shares: -2,187 | Price: $119.47 Total Value: $261,280.89 Shares Owned After: 81,160 | Ownership: D (Direct) [Transaction #19] Security: Common Stock Date: 2026-07-31 | Code: S (Open market sale) Shares: -6,171 | Price: $119.43 Total Value: $737,002.53 Shares Owned After: 74,989 | Ownership: D (Direct) [Transaction #20] Security: Common Stock Date: 2026-07-31 | Code: S (Open market sale) Shares: -4,695 | Price: $119.39 Total Value: $560,536.05 Shares Owned After: 70,294 | Ownership: D (Direct) [Transaction #21] Security: Common Stock Date: 2026-07-31 | Code: S (Open market sale) Shares: -2,864 | Price: $119.40 Total Value: $341,961.60 Shares Owned After: 67,430 | Ownership: D (Direct) [Transaction #22] Security: Common Stock Date: 2026-07-31 | Code: S (Open market sale) Shares: -1,643 | Price: $119.51 Total Value: $196,354.93 Shares Owned After: 65,787 | Ownership: D (Direct) [Transaction #23] Security: Common Stock Date: 2026-07-31 | Code: S (Open market sale) Shares: -1,642 | Price: $119.38 Total Value: $196,021.96 Shares Owned After: 64,145 | Ownership: D (Direct) [Transaction #24] Security: Common Stock Date: 2026-07-31 | Code: S (Open market sale) Shares: -85 | Price: $122.19 Total Value: $10,386.15 Shares Owned After: 64,060 | Ownership: D (Direct) [Transaction #25] Security: Common Stock Date: 2026-07-31 | Code: S (Open market sale) Shares: -326 | Price: $121.69 Total Value: $39,670.94 Shares Owned After: 63,734 | Ownership: D (Direct) [Transaction #26] Security: Common Stock Date: 2026-07-31 | Code: S (Open market sale) Shares: -2,293 | Price: $119.41 Total Value: $273,807.13 Shares Owned After: 61,441 | Ownership: D (Direct) [Transaction #27] Security: Common Stock Date: 2026-08-03 | Code: M (Exercise of derivative) Shares: +6,055 | Price: $105.43 Total Value: $638,378.65 Shares Owned After: 67,496 | Ownership: D (Direct) [Transaction #28] Security: Common Stock Date: 2026-08-03 | Code: S (Open market sale) Shares: -6,055 | Price: $120.43 Total Value: $729,203.65 Shares Owned After: 61,441 | Ownership: D (Direct) Footnotes: [F1] This includes an aggregate of 59,537 shares of common stock issuable pursuant to previously reported restricted stock units have not vested. --- Derivative Transactions --- [Transaction #1] Security: Employee Stock Option (right to buy) Date: 2026-07-31 | Code: M (Exercise of derivative) Shares: -2,918 | Price: $0.00 Exercisable: N/A | Expires: 2034-01-17 Shares Owned After: 1,328 | Ownership: D (Direct) Footnotes: [F2] Options granted on January 18, 2024 and will vest monthly through July 14, 2027 [Transaction #2] Security: Employee Stock Option (right to buy) Date: 2026-07-31 | Code: M (Exercise of derivative) Shares: -2,284 | Price: $0.00 Exercisable: N/A | Expires: 2034-07-14 Shares Owned After: 2,938 | Ownership: D (Direct) Footnotes: [F3] Options granted on July 15, 2024 and will vest monthly through July 15, 2028 [Transaction #3] Security: Employee Stock Option (right to buy) Date: 2026-07-31 | Code: M (Exercise of derivative) Shares: -2,709 | Price: $0.00 Exercisable: N/A | Expires: 2033-07-13 Shares Owned After: 1,233 | Ownership: D (Direct) Footnotes: [F4] Options granted on July 14, 2023 and will vest monthly through July 14, 2027 [Transaction #4] Security: Employee Stock Option (right to buy) Date: 2026-07-31 | Code: M (Exercise of derivative) Shares: -3,148 | Price: $0.00 Exercisable: N/A | Expires: 2028-07-01 Shares Owned After: 0 | Ownership: D (Direct) Footnotes: [F5] As of July 31st, 2026, the award is fully vested and exercisable. [Transaction #5] Security: Employee Stock Option (right to buy) Date: 2026-07-31 | Code: M (Exercise of derivative) Shares: -2,072 | Price: $0.00 Exercisable: N/A | Expires: 2035-01-16 Shares Owned After: 2,665 | Ownership: D (Direct) Footnotes: [F6] Options granted on January 17, 2025 and will vest monthly through July 15, 2028 [Transaction #6] Security: Employee Stock Option (right to buy) Date: 2026-07-31 | Code: M (Exercise of derivative) Shares: -9,459 | Price: $0.00 Exercisable: N/A | Expires: 2029-01-03 Shares Owned After: 0 | Ownership: D (Direct) Footnotes: [F5] As of July 31st, 2026, the award is fully vested and exercisable. [Transaction #7] Security: Employee Stock Option (right to buy) Date: 2026-07-31 | Code: M (Exercise of derivative) Shares: -2,623 | Price: $0.00 Exercisable: N/A | Expires: 2032-01-18 Shares Owned After: 0 | Ownership: D (Direct) Footnotes: [F5] As of July 31st, 2026, the award is fully vested and exercisable. [Transaction #8] Security: Employee Stock Option (right to buy) Date: 2026-07-31 | Code: M (Exercise of derivative) Shares: -2,864 | Price: $0.00 Exercisable: N/A | Expires: 2032-07-01 Shares Owned After: 191 | Ownership: D (Direct) Footnotes: [F5] As of July 31st, 2026, the award is fully vested and exercisable. [Transaction #9] Security: Employee Stock Option (right to buy) Date: 2026-07-31 | Code: M (Exercise of derivative) Shares: -1,643 | Price: $0.00 Exercisable: N/A | Expires: 2030-01-16 Shares Owned After: 0 | Ownership: D (Direct) Footnotes: [F5] As of July 31st, 2026, the award is fully vested and exercisable. [Transaction #10] Security: Employee Stock Option (right to buy) Date: 2026-07-31 | Code: M (Exercise of derivative) Shares: -3,023 | Price: $0.00 Exercisable: N/A | Expires: 2033-01-19 Shares Owned After: 202 | Ownership: D (Direct) Footnotes: [F5] As of July 31st, 2026, the award is fully vested and exercisable. [Transaction #11] Security: Employee Stock Option (right to buy) Date: 2026-07-31 | Code: M (Exercise of derivative) Shares: -2,623 | Price: $0.00 Exercisable: N/A | Expires: 2031-07-01 Shares Owned After: 0 | Ownership: D (Direct) Footnotes: [F5] As of July 31st, 2026, the award is fully vested and exercisable. [Transaction #12] Security: Employee Stock Option (right to buy) Date: 2026-07-31 | Code: M (Exercise of derivative) Shares: -1,642 | Price: $0.00 Exercisable: N/A | Expires: 2029-07-01 Shares Owned After: 0 | Ownership: D (Direct) Footnotes: [F5] As of July 31st, 2026, the award is fully vested and exercisable. [Transaction #13] Security: Employee Stock Option (right to buy) Date: 2026-07-31 | Code: M (Exercise of derivative) Shares: -2,293 | Price: $0.00 Exercisable: N/A | Expires: 2031-01-14 Shares Owned After: 0 | Ownership: D (Direct) Footnotes: [F5] As of July 31st, 2026, the award is fully vested and exercisable. [Transaction #14] Security: Employee Stock Option (right to buy) Date: 2026-07-31 | Code: M (Exercise of derivative) Shares: -85 | Price: $0.00 Exercisable: N/A | Expires: 2030-07-01 Shares Owned After: 2,207 | Ownership: D (Direct) Footnotes: [F5] As of July 31st, 2026, the award is fully vested and exercisable. [Transaction #15] Security: Employee Stock Option (right to buy) Date: 2026-07-31 | Code: M (Exercise of derivative) Shares: -326 | Price: $0.00 Exercisable: N/A | Expires: 2027-11-06 Shares Owned After: 6,055 | Ownership: D (Direct) Footnotes: [F5] As of July 31st, 2026, the award is fully vested and exercisable. [Transaction #16] Security: Employee Stock Option (right to buy) Date: 2026-08-03 | Code: M (Exercise of derivative) Shares: -6,055 | Price: $0.00 Exercisable: N/A | Expires: 2027-11-06 Shares Owned After: 0 | Ownership: D (Direct) Footnotes: [F5] As of July 31st, 2026, the award is fully vested and exercisable. --- Footnotes (Complete Index) --- F1: This includes an aggregate of 59,537 shares of common stock issuable pursuant to previously reported restricted stock units have not vested. F2: Options granted on January 18, 2024 and will vest monthly through July 14, 2027 F3: Options granted on July 15, 2024 and will vest monthly through July 15, 2028 F4: Options granted on July 14, 2023 and will vest monthly through July 14, 2027 F5: As of July 31st, 2026, the award is fully vested and exercisable. F6: Options granted on January 17, 2025 and will vest monthly through July 15, 2028 --- Signature --- /s/ /s/ Elizabeth Feeney, Attorney-In-Fact (2026-08-04)