Vertex (VRTX)

=== SEC Form 4 — Statement of Changes in Beneficial Ownership === Document Type: 4 Period of Report: 2026-07-15 10b5-1 Pre-arranged Plan: No --- Issuer --- Name: VERTEX PHARMACEUTICALS INC / MA (VRTX) CIK: 0000875320 --- Reporting Owner --- Name: Garber Alan M CIK: 0001312907 Role: Director --- Derivative Transactions --- [Transaction #1] Security: Deferred Stock Units Date: 2026-07-15 | Code: A (Grant or award) Shares: +31.56 | Price: $475.28 Shares Owned After: 65.458 | Ownership: D (Direct) Footnotes: [F1] Each deferred stock unit represents one share of common stock and is paid out in common stock upon the earliest to occur of (i) termination of Dr. Garber's service on our board of directors, (ii) a change of control of our company and (iii) Dr. Garber's disability or death. [F1] Each deferred stock unit represents one share of common stock and is paid out in common stock upon the earliest to occur of (i) termination of Dr. Garber's service on our board of directors, (ii) a change of control of our company and (iii) Dr. Garber's disability or death. [F1] Each deferred stock unit represents one share of common stock and is paid out in common stock upon the earliest to occur of (i) termination of Dr. Garber's service on our board of directors, (ii) a change of control of our company and (iii) Dr. Garber's disability or death. --- Footnotes (Complete Index) --- F1: Each deferred stock unit represents one share of common stock and is paid out in common stock upon the earliest to occur of (i) termination of Dr. Garber's service on our board of directors, (ii) a change of control of our company and (iii) Dr. Garber's disability or death. --- Signature --- /s/ /s/ Christiana Stevenson, Attorney-in-Fact (2026-07-17)