Guardant Health, Inc. (GH) · Insider Trading (Form 4) SEC Filing

=== SEC Form 4 — Statement of Changes in Beneficial Ownership === Document Type: 4 Period of Report: 2026-06-26 10b5-1 Pre-arranged Plan: Yes --- Issuer --- Name: Guardant Health, Inc. (GH) CIK: 0001576280 --- Reporting Owner --- Name: Talasaz AmirAli CIK: 0001753159 Role: Director, Officer (Co-Chief Executive Officer) --- Non-Derivative Transactions --- [Transaction #1] Security: Common Stock Date: 2026-06-26 | Code: M (Exercise of derivative) Shares: +111,804 | Price: $4.18 Total Value: $467,340.72 Shares Owned After: 1,998,308 | Ownership: I (Indirect) | Nature: Shares held by Talasaz and Eskandari 2017 Family Trust [Transaction #2] Security: Common Stock Date: 2026-06-26 | Code: S (Open market sale) Shares: -64,037 | Price: $150.49 Total Value: $9,636,838.48 Shares Owned After: 1,934,271 | Ownership: I (Indirect) | Nature: Shares held by Talasaz and Eskandari 2017 Family Trust Footnotes: [F1] Represents the weighted average sales price per share. These shares were sold in multiple transactions at prices ranging from $150.00 to $150.99. The Reporting Person has provided to the Issuer, and undertakes to provide to the staff of the Securities and Exchange Commission or any security holder of the Issuer, upon request, full information regarding the number of shares sold at each separate price within the range. [Transaction #3] Security: Common Stock Date: 2026-06-26 | Code: S (Open market sale) Shares: -52,935 | Price: $151.16 Total Value: $8,001,628.13 Shares Owned After: 1,881,336 | Ownership: I (Indirect) | Nature: Shares held by Talasaz and Eskandari 2017 Family Trust Footnotes: [F2] Represents the weighted average sales price per share. These shares were sold in multiple transactions at prices ranging from $151.00 to $151.79. The Reporting Person has provided to the Issuer, and undertakes to provide to the staff of the Securities and Exchange Commission or any security holder of the Issuer, upon request, full information regarding the number of shares sold at each separate price within the range. [Transaction #4] Security: Common Stock Date: 2026-06-29 | Code: M (Exercise of derivative) Shares: +143,028 | Price: $4.18 Total Value: $597,857.04 Shares Owned After: 2,024,364 | Ownership: I (Indirect) | Nature: Shares held by Talasaz and Eskandari 2017 Family Trust [Transaction #5] Security: Common Stock Date: 2026-06-29 | Code: S (Open market sale) Shares: -25,812 | Price: $150.53 Total Value: $3,885,433.90 Shares Owned After: 1,998,552 | Ownership: I (Indirect) | Nature: Shares held by Talasaz and Eskandari 2017 Family Trust Footnotes: [F1] Represents the weighted average sales price per share. These shares were sold in multiple transactions at prices ranging from $150.00 to $150.99. The Reporting Person has provided to the Issuer, and undertakes to provide to the staff of the Securities and Exchange Commission or any security holder of the Issuer, upon request, full information regarding the number of shares sold at each separate price within the range. [Transaction #6] Security: Common Stock Date: 2026-06-29 | Code: S (Open market sale) Shares: -70,513 | Price: $151.47 Total Value: $10,680,315.01 Shares Owned After: 1,928,039 | Ownership: I (Indirect) | Nature: Shares held by Talasaz and Eskandari 2017 Family Trust Footnotes: [F3] Represents the weighted average sales price per share. These shares were sold in multiple transactions at prices ranging from $151.00 to $151.99. The Reporting Person has provided to the Issuer, and undertakes to provide to the staff of the Securities and Exchange Commission or any security holder of the Issuer, upon request, full information regarding the number of shares sold at each separate price within the range. [Transaction #7] Security: Common Stock Date: 2026-06-29 | Code: S (Open market sale) Shares: -46,663 | Price: $152.20 Total Value: $7,102,318.58 Shares Owned After: 1,881,376 | Ownership: I (Indirect) | Nature: Shares held by Talasaz and Eskandari 2017 Family Trust Footnotes: [F4] Represents the weighted average sales price per share. These shares were sold in multiple transactions at prices ranging from $152.00 to $152.68. The Reporting Person has provided to the Issuer, and undertakes to provide to the staff of the Securities and Exchange Commission or any security holder of the Issuer, upon request, full information regarding the number of shares sold at each separate price within the range. [Transaction #8] Security: Common Stock Date: 2026-06-29 | Code: S (Open market sale) Shares: -40 | Price: $153.00 Total Value: $6,120.00 Shares Owned After: 1,881,336 | Ownership: I (Indirect) | Nature: Shares held by Talasaz and Eskandari 2017 Family Trust --- Derivative Transactions --- [Transaction #1] Security: Stock Option (Right to Buy) Date: 2026-06-26 | Code: M (Exercise of derivative) Shares: -111,804 | Price: $0.00 Exercisable: N/A | Expires: 2027-07-14 Shares Owned After: 172,025 | Ownership: D (Direct) Footnotes: [F5] The stock option vested in equal monthly installments over 48 months commencing on April 23, 2017. [Transaction #2] Security: Stock Option (Right to Buy) Date: 2026-06-29 | Code: M (Exercise of derivative) Shares: -143,028 | Price: $0.00 Exercisable: N/A | Expires: 2027-07-14 Shares Owned After: 28,997 | Ownership: D (Direct) Footnotes: [F5] The stock option vested in equal monthly installments over 48 months commencing on April 23, 2017. --- Footnotes (Complete Index) --- F1: Represents the weighted average sales price per share. These shares were sold in multiple transactions at prices ranging from $150.00 to $150.99. The Reporting Person has provided to the Issuer, and undertakes to provide to the staff of the Securities and Exchange Commission or any security holder of the Issuer, upon request, full information regarding the number of shares sold at each separate price within the range. F2: Represents the weighted average sales price per share. These shares were sold in multiple transactions at prices ranging from $151.00 to $151.79. The Reporting Person has provided to the Issuer, and undertakes to provide to the staff of the Securities and Exchange Commission or any security holder of the Issuer, upon request, full information regarding the number of shares sold at each separate price within the range. F3: Represents the weighted average sales price per share. These shares were sold in multiple transactions at prices ranging from $151.00 to $151.99. The Reporting Person has provided to the Issuer, and undertakes to provide to the staff of the Securities and Exchange Commission or any security holder of the Issuer, upon request, full information regarding the number of shares sold at each separate price within the range. F4: Represents the weighted average sales price per share. These shares were sold in multiple transactions at prices ranging from $152.00 to $152.68. The Reporting Person has provided to the Issuer, and undertakes to provide to the staff of the Securities and Exchange Commission or any security holder of the Issuer, upon request, full information regarding the number of shares sold at each separate price within the range. F5: The stock option vested in equal monthly installments over 48 months commencing on April 23, 2017. --- Signature --- /s/ /s/ John G. Saia, as attorney-in-fact for AmirAli Talasaz (2026-06-30)