Guardant Health, Inc. (GH) · Insider Trading (Form 4) SEC Filing

=== SEC Form 4 — Statement of Changes in Beneficial Ownership === Document Type: 4 Period of Report: 2026-06-30 10b5-1 Pre-arranged Plan: No --- Issuer --- Name: Guardant Health, Inc. (GH) CIK: 0001576280 --- Reporting Owner --- Name: Talasaz AmirAli CIK: 0001753159 Role: Director, Officer (Co-Chief Executive Officer) --- Non-Derivative Transactions --- [Transaction #1] Security: Common Stock Date: 2026-06-30 | Code: M (Exercise of derivative) Shares: +2,817 | Price: $0.00 Shares Owned After: 1,884,153 | Ownership: I (Indirect) | Nature: Shares held by Talasaz and Eskandari 2017 Family Trust [Transaction #2] Security: Common Stock Date: 2026-06-30 | Code: F (Payment of exercise/tax) Shares: -1,428 | Price: $150.03 Total Value: $214,242.84 Shares Owned After: 1,882,725 | Ownership: I (Indirect) | Nature: Shares held by Talasaz and Eskandari 2017 Family Trust Footnotes: [F1] These shares were retained by the Company in order to meet the tax withholding obligations of the award-holder in connection with the vesting of an installment of the restricted stock units. The amount retained by the Company was not in excess of the amount of the tax liability. [Transaction #3] Security: Common Stock Date: 2026-07-01 | Code: M (Exercise of derivative) Shares: +23,997 | Price: $0.00 Shares Owned After: 1,906,722 | Ownership: I (Indirect) | Nature: Shares held by Talasaz and Eskandari 2017 Family Trust [Transaction #4] Security: Common Stock Date: 2026-07-01 | Code: M (Exercise of derivative) Shares: +9,715 | Price: $0.00 Shares Owned After: 1,916,437 | Ownership: I (Indirect) | Nature: Shares held by Talasaz and Eskandari 2017 Family Trust [Transaction #5] Security: Common Stock Date: 2026-07-01 | Code: F (Payment of exercise/tax) Shares: -17,086 | Price: $170.77 Total Value: $2,917,776.22 Shares Owned After: 1,899,351 | Ownership: I (Indirect) | Nature: Shares held by Talasaz and Eskandari 2017 Family Trust Footnotes: [F1] These shares were retained by the Company in order to meet the tax withholding obligations of the award-holder in connection with the vesting of an installment of the restricted stock units. The amount retained by the Company was not in excess of the amount of the tax liability. --- Derivative Transactions --- [Transaction #1] Security: Restricted Stock Units Date: 2026-06-30 | Code: M (Exercise of derivative) Shares: -2,817 | Price: $0.00 Shares Owned After: 5,634 | Ownership: D (Direct) Footnotes: [F2] This represents a restricted stock unit award granted on March 17, 2026 that vests in four equal installments on the last day of each calendar quarter, March 31, 2026, June 30, 2026, September 30, 2026, and December 31, 2026. [F3] Not applicable for Restricted Stock Units. [Transaction #2] Security: Restricted Stock Units Date: 2026-07-01 | Code: M (Exercise of derivative) Shares: -23,997 | Price: $0.00 Shares Owned After: 47,995 | Ownership: D (Direct) Footnotes: [F4] This represents a restricted stock unit award granted on March 18, 2024 that vests over a three-year period. 33% of the shares subject to such award vested on January 1, 2025 and the remaining 67% of the shares vests in equal quarterly installments over the remaining two-year period thereafter. [F3] Not applicable for Restricted Stock Units. [Transaction #3] Security: Restricted Stock Units Date: 2026-07-01 | Code: M (Exercise of derivative) Shares: -9,715 | Price: $0.00 Shares Owned After: 58,296 | Ownership: D (Direct) Footnotes: [F5] This represents a restricted stock unit award granted on March 12, 2025 that vests over a three-year period. 33% of the shares subject to such award vested on January 1, 2026 and the remaining 67% of the shares vests in equal quarterly installments over the remaining two-year period thereafter. [F3] Not applicable for Restricted Stock Units. --- Footnotes (Complete Index) --- F1: These shares were retained by the Company in order to meet the tax withholding obligations of the award-holder in connection with the vesting of an installment of the restricted stock units. The amount retained by the Company was not in excess of the amount of the tax liability. F2: This represents a restricted stock unit award granted on March 17, 2026 that vests in four equal installments on the last day of each calendar quarter, March 31, 2026, June 30, 2026, September 30, 2026, and December 31, 2026. F3: Not applicable for Restricted Stock Units. F4: This represents a restricted stock unit award granted on March 18, 2024 that vests over a three-year period. 33% of the shares subject to such award vested on January 1, 2025 and the remaining 67% of the shares vests in equal quarterly installments over the remaining two-year period thereafter. F5: This represents a restricted stock unit award granted on March 12, 2025 that vests over a three-year period. 33% of the shares subject to such award vested on January 1, 2026 and the remaining 67% of the shares vests in equal quarterly installments over the remaining two-year period thereafter. --- Signature --- /s/ /s/ John G. Saia, as attorney-in-fact for AmirAli Talasaz (2026-07-02)