Guardant Health (GH) 4: Saia John G. bought 974 shares of Common Stock at $N/A on 2… (Jan 5, 2026)

=== SEC Form 4 — Statement of Changes in Beneficial Ownership === Document Type: 4 Period of Report: 2026-01-01 10b5-1 Pre-arranged Plan: No --- Issuer --- Name: Guardant Health, Inc. (GH) CIK: 0001576280 --- Reporting Owner --- Name: Saia John G. CIK: 0001737840 Role: Officer (Chief Legal Officer) --- Non-Derivative Transactions --- [Transaction #1] Security: Common Stock Date: 2026-01-01 | Code: M (Exercise of derivative) Shares: +974 | Price: $0.00 Shares Owned After: 44,631 | Ownership: D (Direct) [Transaction #2] Security: Common Stock Date: 2026-01-01 | Code: M (Exercise of derivative) Shares: +7,792 | Price: $0.00 Shares Owned After: 52,423 | Ownership: D (Direct) [Transaction #3] Security: Common Stock Date: 2026-01-01 | Code: M (Exercise of derivative) Shares: +1,667 | Price: $0.00 Shares Owned After: 54,090 | Ownership: D (Direct) [Transaction #4] Security: Common Stock Date: 2026-01-01 | Code: M (Exercise of derivative) Shares: +5,688 | Price: $0.00 Shares Owned After: 59,778 | Ownership: D (Direct) [Transaction #5] Security: Common Stock Date: 2026-01-01 | Code: M (Exercise of derivative) Shares: +2,925 | Price: $0.00 Shares Owned After: 62,703 | Ownership: D (Direct) [Transaction #6] Security: Common Stock Date: 2026-01-01 | Code: F (Payment of exercise/tax) Shares: -9,989 | Price: $102.14 Total Value: $1,020,276.46 Shares Owned After: 52,714 | Ownership: D (Direct) Footnotes: [F1] These shares were retained by the Company in order to meet the tax withholding obligations of the award-holder in connection with the vesting of an installment of the restricted stock units. The amount retained by the Company was not in excess of the amount of the tax liability. --- Derivative Transactions --- [Transaction #1] Security: Restricted Stock Units Date: 2026-01-01 | Code: M (Exercise of derivative) Shares: -974 | Price: $0.00 Shares Owned After: 2,922 | Ownership: D (Direct) Footnotes: [F2] This represents a restricted stock unit award granted on November 7, 2022 that vests over a four-year period. 25% of the shares subject to such award vested on October 1, 2023 and the remaining 75% of the shares vests in equal quarterly installments over the remaining three-year period thereafter. [F3] Not applicable for Restricted Stock Units. [Transaction #2] Security: Performance-Based Restricted Stock Units Date: 2026-01-01 | Code: M (Exercise of derivative) Shares: -7,792 | Price: $0.00 Shares Owned After: 0 | Ownership: D (Direct) Footnotes: [F4] This represents a performance-based restricted stock unit award granted on June 7, 2023, with a performance metric and 2-year vest period that was achieved. The shares vested on January 1, 2026. [F3] Not applicable for Restricted Stock Units. [Transaction #3] Security: Restricted Stock Units Date: 2026-01-01 | Code: M (Exercise of derivative) Shares: -1,667 | Price: $0.00 Shares Owned After: 5,002 | Ownership: D (Direct) Footnotes: [F5] This represents a restricted stock unit award granted on December 13, 2023 that vests over a three-year period. 33% of the shares subject to such award vested on October 1, 2024 and the remaining 67% of the shares vests in equal quarterly installments over the remaining two-year period thereafter. [F3] Not applicable for Restricted Stock Units. [Transaction #4] Security: Performance-Based Restricted Stock Units Date: 2026-01-01 | Code: M (Exercise of derivative) Shares: -5,688 | Price: $0.00 Shares Owned After: 5,688 | Ownership: D (Direct) Footnotes: [F6] This represents a performance-based restricted stock unit award granted on February 26, 2024, that a performance metric was achieved and that 33% of the shares subject to such award vested on March 1, 2025. 33% of the shares subject to the award vested on January 1, 2026, and the remaining 34% of the shares subject to the award will vest on January 1, 2027. [F3] Not applicable for Restricted Stock Units. [Transaction #5] Security: Restricted Stock Units Date: 2026-01-01 | Code: M (Exercise of derivative) Shares: -2,925 | Price: $0.00 Shares Owned After: 20,476 | Ownership: D (Direct) Footnotes: [F7] This represents a restricted stock unit award granted on November 8, 2024 that vests over a three-year period. 33% of the shares subject to such award vested on October 1, 2025 and the remaining 67% of the shares vests in equal quarterly installments over the remaining two-year period thereafter. [F3] Not applicable for Restricted Stock Units. --- Holdings --- [Holding #1] Security: Performance-Based Restricted Stock Units Ownership: D (Direct) Footnotes: [F4] This represents a performance-based restricted stock unit award granted on June 7, 2023, with a performance metric and 2-year vest period that was achieved. The shares vested on January 1, 2026. [F3] Not applicable for Restricted Stock Units. --- Footnotes (Complete Index) --- F1: These shares were retained by the Company in order to meet the tax withholding obligations of the award-holder in connection with the vesting of an installment of the restricted stock units. The amount retained by the Company was not in excess of the amount of the tax liability. F2: This represents a restricted stock unit award granted on November 7, 2022 that vests over a four-year period. 25% of the shares subject to such award vested on October 1, 2023 and the remaining 75% of the shares vests in equal quarterly installments over the remaining three-year period thereafter. F3: Not applicable for Restricted Stock Units. F4: This represents a performance-based restricted stock unit award granted on June 7, 2023, with a performance metric and 2-year vest period that was achieved. The shares vested on January 1, 2026. F5: This represents a restricted stock unit award granted on December 13, 2023 that vests over a three-year period. 33% of the shares subject to such award vested on October 1, 2024 and the remaining 67% of the shares vests in equal quarterly installments over the remaining two-year period thereafter. F6: This represents a performance-based restricted stock unit award granted on February 26, 2024, that a performance metric was achieved and that 33% of the shares subject to such award vested on March 1, 2025. 33% of the shares subject to the award vested on January 1, 2026, and the remaining 34% of the shares subject to the award will vest on January 1, 2027. F7: This represents a restricted stock unit award granted on November 8, 2024 that vests over a three-year period. 33% of the shares subject to such award vested on October 1, 2025 and the remaining 67% of the shares vests in equal quarterly installments over the remaining two-year period thereafter. --- Signature --- /s/ /s/ John G. Saia (2026-01-05)