Guardant Health (GH) 4: Saia John G. bought 7,792 shares of Common Stock at $N/A on… (Mar 17, 2026)

=== SEC Form 4 — Statement of Changes in Beneficial Ownership === Document Type: 4 Period of Report: 2026-03-15 10b5-1 Pre-arranged Plan: No --- Issuer --- Name: Guardant Health, Inc. (GH) CIK: 0001576280 --- Reporting Owner --- Name: Saia John G. CIK: 0001737840 Role: Officer (Chief Legal Officer) --- Non-Derivative Transactions --- [Transaction #1] Security: Common Stock Date: 2026-03-15 | Code: M (Exercise of derivative) Shares: +7,792 | Price: $0.00 Shares Owned After: 60,506 | Ownership: D (Direct) [Transaction #2] Security: Common Stock Date: 2026-03-15 | Code: M (Exercise of derivative) Shares: +1,019 | Price: $0.00 Shares Owned After: 61,525 | Ownership: D (Direct) [Transaction #3] Security: Common Stock Date: 2026-03-15 | Code: F (Payment of exercise/tax) Shares: -4,622 | Price: $85.49 Total Value: $395,134.78 Shares Owned After: 56,903 | Ownership: D (Direct) Footnotes: [F1] These shares were retained by the Company in order to meet the tax withholding obligations of the award-holder in connection with the vesting of an installment of the restricted stock units. The amount retained by the Company was not in excess of the amount of the tax liability. --- Derivative Transactions --- [Transaction #1] Security: Performance-Based Restricted Stock Units Date: 2026-03-15 | Code: M (Exercise of derivative) Shares: -7,792 | Price: $0.00 Shares Owned After: 0 | Ownership: D (Direct) Footnotes: [F2] This represents a performance-based restricted stock unit award granted on June 7, 2023 with a 3-year performance metric. The second tranche metric was achieved and the shares vested on March 15, 2026. [F3] Not applicable for Restricted Stock Units. [Transaction #2] Security: Restricted Stock Units Date: 2026-03-15 | Code: M (Exercise of derivative) Shares: -1,019 | Price: $0.00 Shares Owned After: 1,020 | Ownership: D (Direct) Footnotes: [F4] This represents a restricted stock unit award granted on June 9, 2023 that vests over a three-year period. 33% of the shares subject to such award vested on June 15, 2024 and the remaining 67% of the shares vests in equal quarterly installments over the remaining two-year period thereafter. [F3] Not applicable for Restricted Stock Units. --- Footnotes (Complete Index) --- F1: These shares were retained by the Company in order to meet the tax withholding obligations of the award-holder in connection with the vesting of an installment of the restricted stock units. The amount retained by the Company was not in excess of the amount of the tax liability. F2: This represents a performance-based restricted stock unit award granted on June 7, 2023 with a 3-year performance metric. The second tranche metric was achieved and the shares vested on March 15, 2026. F3: Not applicable for Restricted Stock Units. F4: This represents a restricted stock unit award granted on June 9, 2023 that vests over a three-year period. 33% of the shares subject to such award vested on June 15, 2024 and the remaining 67% of the shares vests in equal quarterly installments over the remaining two-year period thereafter. --- Signature --- /s/ /s/ John G. Saia (2026-03-17)