Guardant Health (GH) 4: Bell Michael Brian bought 1,233 shares of Common Stock at $… (Mar 17, 2026)

=== SEC Form 4 — Statement of Changes in Beneficial Ownership === Document Type: 4 Period of Report: 2026-03-15 10b5-1 Pre-arranged Plan: No --- Issuer --- Name: Guardant Health, Inc. (GH) CIK: 0001576280 --- Reporting Owner --- Name: Bell Michael Brian CIK: 0001702824 Role: Officer (Chief Financial Officer) --- Non-Derivative Transactions --- [Transaction #1] Security: Common Stock Date: 2026-03-15 | Code: M (Exercise of derivative) Shares: +1,233 | Price: $0.00 Shares Owned After: 41,457 | Ownership: D (Direct) [Transaction #2] Security: Common Stock Date: 2026-03-15 | Code: M (Exercise of derivative) Shares: +10,518 | Price: $0.00 Shares Owned After: 51,975 | Ownership: D (Direct) [Transaction #3] Security: Common Stock Date: 2026-03-15 | Code: M (Exercise of derivative) Shares: +2,039 | Price: $0.00 Shares Owned After: 54,014 | Ownership: D (Direct) [Transaction #4] Security: Common Stock Date: 2026-03-15 | Code: F (Payment of exercise/tax) Shares: -7,413 | Price: $85.49 Total Value: $633,737.37 Shares Owned After: 46,601 | Ownership: D (Direct) Footnotes: [F1] These shares were retained by the Company in order to meet the tax withholding obligations of the award-holder in connection with the vesting of an installment of the restricted stock units. The amount retained by the Company was not in excess of the amount of the tax liability. [Transaction #5] Security: Common Stock Date: 2026-03-16 | Code: S (Open market sale) Shares: -3,000 | Price: $87.04 Total Value: $261,111.00 Shares Owned After: 43,601 | Ownership: D (Direct) Footnotes: [F2] Represents the weighted average sales price per share. These shares were sold in multiple transactions at prices ranging from $87.0001 to $87.1500. The Reporting Person has provided to the Issuer, and undertakes to provide to the staff of the Securities and Exchange Commission or any security holder of the Issuer, upon request, full information regarding the number of shares sold at each separate price within the range. --- Derivative Transactions --- [Transaction #1] Security: Restricted Stock Units Date: 2026-03-15 | Code: M (Exercise of derivative) Shares: -1,233 | Price: $0.00 Shares Owned After: 0 | Ownership: D (Direct) Footnotes: [F3] This represents a restricted stock unit award granted on May 9, 2022 that vested over a four-year period. 25% of the shares subject to such award vested on March 15, 2023 and the remaining 75% of the shares vested in equal quarterly installments over the remaining three-year period thereafter. [F4] Not applicable for Restricted Stock Units. [Transaction #2] Security: Performance-Based Restricted Stock Units Date: 2026-03-15 | Code: M (Exercise of derivative) Shares: -10,518 | Price: $0.00 Shares Owned After: 0 | Ownership: D (Direct) Footnotes: [F5] This represents a performance-based restricted stock unit award granted on June 7, 2023 with a 3-year performance metric. The second tranche metric was achieved and the shares vested on March 15, 2026. [F4] Not applicable for Restricted Stock Units. [Transaction #3] Security: Restricted Stock Units Date: 2026-03-15 | Code: M (Exercise of derivative) Shares: -2,039 | Price: $0.00 Shares Owned After: 2,039 | Ownership: D (Direct) Footnotes: [F6] This represents a restricted stock unit award granted on June 9, 2023 that vests over a three-year period. 33% of the shares subject to such award vested on June 15, 2024 and the remaining 67% of the shares vests in equal quarterly installments over the remaining two-year period thereafter. [F4] Not applicable for Restricted Stock Units. --- Footnotes (Complete Index) --- F1: These shares were retained by the Company in order to meet the tax withholding obligations of the award-holder in connection with the vesting of an installment of the restricted stock units. The amount retained by the Company was not in excess of the amount of the tax liability. F2: Represents the weighted average sales price per share. These shares were sold in multiple transactions at prices ranging from $87.0001 to $87.1500. The Reporting Person has provided to the Issuer, and undertakes to provide to the staff of the Securities and Exchange Commission or any security holder of the Issuer, upon request, full information regarding the number of shares sold at each separate price within the range. F3: This represents a restricted stock unit award granted on May 9, 2022 that vested over a four-year period. 25% of the shares subject to such award vested on March 15, 2023 and the remaining 75% of the shares vested in equal quarterly installments over the remaining three-year period thereafter. F4: Not applicable for Restricted Stock Units. F5: This represents a performance-based restricted stock unit award granted on June 7, 2023 with a 3-year performance metric. The second tranche metric was achieved and the shares vested on March 15, 2026. F6: This represents a restricted stock unit award granted on June 9, 2023 that vests over a three-year period. 33% of the shares subject to such award vested on June 15, 2024 and the remaining 67% of the shares vests in equal quarterly installments over the remaining two-year period thereafter. --- Signature --- /s/ /s/ John G. Saia, as attorney-in-fact for Michael Brian Bell (2026-03-17)