Vertex (VRTX) 4: MCKENZIE DIANA bought 943 shares of Common Stock at $N/A on… (May 5, 2026)

=== SEC Form 4 — Statement of Changes in Beneficial Ownership === Document Type: 4 Period of Report: 2026-05-01 10b5-1 Pre-arranged Plan: No --- Issuer --- Name: VERTEX PHARMACEUTICALS INC / MA (VRTX) CIK: 0000875320 --- Reporting Owner --- Name: MCKENZIE DIANA CIK: 0001754648 Role: Director --- Non-Derivative Transactions --- [Transaction #1] Security: Common Stock Date: 2026-05-01 | Code: A (Grant or award) Shares: +943 | Price: $0.00 Shares Owned After: 3,174 | Ownership: D (Direct) Footnotes: [F1] Restricted stock unit award that vests, subject to certain limited exceptions, on the first anniversary of the grant date. [Transaction #2] Security: Common Stock Date: 2026-05-01 | Code: D (Sale to issuer) Shares: -796 Shares Owned After: 2,378 | Ownership: D (Direct) Footnotes: [F2] Upon the vesting of restricted stock units granted to Ms. McKenzie on May 1, 2025, Ms. McKenzie deferred the receipt of 796 shares of common stock and received instead 796 deferred stock units pursuant to our deferred compensation plan. As a result, Ms. McKenzie is reporting the disposition of 796 shares of common stock in exchange for an equal number of deferred stock units. --- Derivative Transactions --- [Transaction #1] Security: Deferred Stock Units Date: 2026-05-01 | Code: A (Grant or award) Shares: +796 Shares Owned After: 7,787.483 | Ownership: D (Direct) Footnotes: [F3] Each deferred stock unit represents one share of common stock and is paid out in common stock upon the earliest to occur of (i) termination of Ms. McKenzie's service on our board of directors, (ii) a change of control of our company and (iii) Ms. McKenzie's disability or death. [F2] Upon the vesting of restricted stock units granted to Ms. McKenzie on May 1, 2025, Ms. McKenzie deferred the receipt of 796 shares of common stock and received instead 796 deferred stock units pursuant to our deferred compensation plan. As a result, Ms. McKenzie is reporting the disposition of 796 shares of common stock in exchange for an equal number of deferred stock units. [F3] Each deferred stock unit represents one share of common stock and is paid out in common stock upon the earliest to occur of (i) termination of Ms. McKenzie's service on our board of directors, (ii) a change of control of our company and (iii) Ms. McKenzie's disability or death. [F3] Each deferred stock unit represents one share of common stock and is paid out in common stock upon the earliest to occur of (i) termination of Ms. McKenzie's service on our board of directors, (ii) a change of control of our company and (iii) Ms. McKenzie's disability or death. --- Holdings --- [Holding #1] Security: Common Stock Ownership: I (Indirect) --- Footnotes (Complete Index) --- F1: Restricted stock unit award that vests, subject to certain limited exceptions, on the first anniversary of the grant date. F2: Upon the vesting of restricted stock units granted to Ms. McKenzie on May 1, 2025, Ms. McKenzie deferred the receipt of 796 shares of common stock and received instead 796 deferred stock units pursuant to our deferred compensation plan. As a result, Ms. McKenzie is reporting the disposition of 796 shares of common stock in exchange for an equal number of deferred stock units. F3: Each deferred stock unit represents one share of common stock and is paid out in common stock upon the earliest to occur of (i) termination of Ms. McKenzie's service on our board of directors, (ii) a change of control of our company and (iii) Ms. McKenzie's disability or death. --- Signature --- /s/ /s/ Christiana Stevenson, Attorney-in-Fact (2026-05-05)