Guardant Health (GH)

=== SEC Form 4 — Statement of Changes in Beneficial Ownership === Document Type: 4 Period of Report: 2026-05-15 10b5-1 Pre-arranged Plan: No --- Issuer --- Name: Guardant Health, Inc. (GH) CIK: 0001576280 --- Reporting Owner --- Name: Chudova Darya CIK: 0001977179 Role: Officer (Chief Technology Officer) --- Non-Derivative Transactions --- [Transaction #1] Security: Common Stock Date: 2026-05-15 | Code: M (Exercise of derivative) Shares: +8,705 | Price: $0.00 Shares Owned After: 79,081 | Ownership: D (Direct) [Transaction #2] Security: Common Stock Date: 2026-05-15 | Code: F (Payment of exercise/tax) Shares: -4,679 | Price: $94.92 Total Value: $444,130.68 Shares Owned After: 74,402 | Ownership: D (Direct) Footnotes: [F1] These shares were retained by the Company in order to meet the tax withholding obligations of the award-holder in connection with the vesting of an installment of the restricted stock units. The amount retained by the Company was not in excess of the amount of the tax liability. --- Derivative Transactions --- [Transaction #1] Security: Restricted Stock Units Date: 2026-05-15 | Code: M (Exercise of derivative) Shares: -8,705 | Price: $0.00 Shares Owned After: 8,706 | Ownership: D (Direct) Footnotes: [F2] This represents a restricted stock unit award granted on August 7, 2023 and vests over a four-year period. 25% of the shares subject to such award vested on May 15, 2024 and the remaining 75% vests annually during the three-year period thereafter. [F3] Not applicable for Restricted Stock Units. --- Footnotes (Complete Index) --- F1: These shares were retained by the Company in order to meet the tax withholding obligations of the award-holder in connection with the vesting of an installment of the restricted stock units. The amount retained by the Company was not in excess of the amount of the tax liability. F2: This represents a restricted stock unit award granted on August 7, 2023 and vests over a four-year period. 25% of the shares subject to such award vested on May 15, 2024 and the remaining 75% vests annually during the three-year period thereafter. F3: Not applicable for Restricted Stock Units. --- Signature --- /s/ /s/ John G. Saia, as attorney-in-fact for Darya Chudova (2026-05-19)