=== SEC Form 4 — Statement of Changes in Beneficial Ownership ===
Document Type: 4
Period of Report: 2026-05-20
10b5-1 Pre-arranged Plan: Yes
--- Issuer ---
Name: Guardant Health, Inc. (GH)
CIK: 0001576280
--- Reporting Owner ---
Name: Talasaz AmirAli
CIK: 0001753159
Role: Director, Officer (Co-Chief Executive Officer)
--- Non-Derivative Transactions ---
[Transaction #1]
Security: Common Stock
Date: 2026-05-20 | Code: S (Open market sale)
Shares: -200 | Price: $100.95
Total Value: $20,190.00
Shares Owned After: 2,096,304 | Ownership: I (Indirect) | Nature: Shares held by Talasaz and Eskandari 2017 Family Trust
[Transaction #2]
Security: Common Stock
Date: 2026-05-20 | Code: S (Open market sale)
Shares: -900 | Price: $102.57
Total Value: $92,313.00
Shares Owned After: 2,095,404 | Ownership: I (Indirect) | Nature: Shares held by Talasaz and Eskandari 2017 Family Trust
Footnotes:
[F1] Represents the weighted average sales price per share. These shares were sold in multiple transactions at prices ranging from $102.29 to $103.06. The Reporting Person has provided to the Issuer, and undertakes to provide to the staff of the Securities and Exchange Commission or any security holder of the Issuer, upon request, full information regarding the number of shares sold at each separate price within the range.
[Transaction #3]
Security: Common Stock
Date: 2026-05-20 | Code: S (Open market sale)
Shares: -1,366 | Price: $103.82
Total Value: $141,815.11
Shares Owned After: 2,094,038 | Ownership: I (Indirect) | Nature: Shares held by Talasaz and Eskandari 2017 Family Trust
Footnotes:
[F2] Represents the weighted average sales price per share. These shares were sold in multiple transactions at prices ranging from $103.40 to $104.26. The Reporting Person has provided to the Issuer, and undertakes to provide to the staff of the Securities and Exchange Commission or any security holder of the Issuer, upon request, full information regarding the number of shares sold at each separate price within the range.
[Transaction #4]
Security: Common Stock
Date: 2026-05-20 | Code: S (Open market sale)
Shares: -11,919 | Price: $105.01
Total Value: $1,251,589.16
Shares Owned After: 2,082,119 | Ownership: I (Indirect) | Nature: Shares held by Talasaz and Eskandari 2017 Family Trust
Footnotes:
[F3] Represents the weighted average sales price per share. These shares were sold in multiple transactions at prices ranging from $104.400 to $105.39. The Reporting Person has provided to the Issuer, and undertakes to provide to the staff of the Securities and Exchange Commission or any security holder of the Issuer, upon request, full information regarding the number of shares sold at each separate price within the range.
[Transaction #5]
Security: Common Stock
Date: 2026-05-20 | Code: S (Open market sale)
Shares: -1,200 | Price: $105.88
Total Value: $127,050.00
Shares Owned After: 2,080,919 | Ownership: I (Indirect) | Nature: Shares held by Talasaz and Eskandari 2017 Family Trust
Footnotes:
[F4] Represents the weighted average sales price per share. These shares were sold in multiple transactions at prices ranging from $105.49 to $106.42. The Reporting Person has provided to the Issuer, and undertakes to provide to the staff of the Securities and Exchange Commission or any security holder of the Issuer, upon request, full information regarding the number of shares sold at each separate price within the range.
[Transaction #6]
Security: Common Stock
Date: 2026-05-20 | Code: S (Open market sale)
Shares: -21,171 | Price: $106.99
Total Value: $2,265,125.51
Shares Owned After: 2,059,748 | Ownership: I (Indirect) | Nature: Shares held by Talasaz and Eskandari 2017 Family Trust
Footnotes:
[F5] Represents the weighted average sales price per share. These shares were sold in multiple transactions at prices ranging from $106.57 to $107.52. The Reporting Person has provided to the Issuer, and undertakes to provide to the staff of the Securities and Exchange Commission or any security holder of the Issuer, upon request, full information regarding the number of shares sold at each separate price within the range.
[Transaction #7]
Security: Common Stock
Date: 2026-05-20 | Code: S (Open market sale)
Shares: -33,069 | Price: $108.11
Total Value: $3,574,960.62
Shares Owned After: 2,026,679 | Ownership: I (Indirect) | Nature: Shares held by Talasaz and Eskandari 2017 Family Trust
Footnotes:
[F6] Represents the weighted average sales price per share. These shares were sold in multiple transactions at prices ranging from $107.59 to $108.57. The Reporting Person has provided to the Issuer, and undertakes to provide to the staff of the Securities and Exchange Commission or any security holder of the Issuer, upon request, full information regarding the number of shares sold at each separate price within the range.
[Transaction #8]
Security: Common Stock
Date: 2026-05-20 | Code: S (Open market sale)
Shares: -9,852 | Price: $108.97
Total Value: $1,073,546.82
Shares Owned After: 2,016,827 | Ownership: I (Indirect) | Nature: Shares held by Talasaz and Eskandari 2017 Family Trust
Footnotes:
[F7] Represents the weighted average sales price per share. These shares were sold in multiple transactions at prices ranging from $108.59 to $109.56. The Reporting Person has provided to the Issuer, and undertakes to provide to the staff of the Securities and Exchange Commission or any security holder of the Issuer, upon request, full information regarding the number of shares sold at each separate price within the range.
[Transaction #9]
Security: Common Stock
Date: 2026-05-20 | Code: S (Open market sale)
Shares: -28,908 | Price: $110.10
Total Value: $3,182,652.28
Shares Owned After: 1,987,919 | Ownership: I (Indirect) | Nature: Shares held by Talasaz and Eskandari 2017 Family Trust
Footnotes:
[F8] Represents the weighted average sales price per share. These shares were sold in multiple transactions at prices ranging from $109.66 to $110.58. The Reporting Person has provided to the Issuer, and undertakes to provide to the staff of the Securities and Exchange Commission or any security holder of the Issuer, upon request, full information regarding the number of shares sold at each separate price within the range.
[Transaction #10]
Security: Common Stock
Date: 2026-05-20 | Code: S (Open market sale)
Shares: -37,163 | Price: $111.14
Total Value: $4,130,470.49
Shares Owned After: 1,950,756 | Ownership: I (Indirect) | Nature: Shares held by Talasaz and Eskandari 2017 Family Trust
Footnotes:
[F9] Represents the weighted average sales price per share. These shares were sold in multiple transactions at prices ranging from $110.72 to $111.71. The Reporting Person has provided to the Issuer, and undertakes to provide to the staff of the Securities and Exchange Commission or any security holder of the Issuer, upon request, full information regarding the number of shares sold at each separate price within the range.
[Transaction #11]
Security: Common Stock
Date: 2026-05-20 | Code: S (Open market sale)
Shares: -37,900 | Price: $112.02
Total Value: $4,245,546.63
Shares Owned After: 1,912,856 | Ownership: I (Indirect) | Nature: Shares held by Talasaz and Eskandari 2017 Family Trust
Footnotes:
[F10] Represents the weighted average sales price per share. These shares were sold in multiple transactions at prices ranging from $111.73 to $112.70. The Reporting Person has provided to the Issuer, and undertakes to provide to the staff of the Securities and Exchange Commission or any security holder of the Issuer, upon request, full information regarding the number of shares sold at each separate price within the range.
[Transaction #12]
Security: Common Stock
Date: 2026-05-20 | Code: S (Open market sale)
Shares: -26,352 | Price: $112.76
Total Value: $2,971,430.44
Shares Owned After: 1,886,504 | Ownership: I (Indirect) | Nature: Shares held by Talasaz and Eskandari 2017 Family Trust
Footnotes:
[F11] Represents the weighted average sales price per share. These shares were sold in multiple transactions at prices ranging from $112.74 to $112.93. The Reporting Person has provided to the Issuer, and undertakes to provide to the staff of the Securities and Exchange Commission or any security holder of the Issuer, upon request, full information regarding the number of shares sold at each separate price within the range.
--- Footnotes (Complete Index) ---
F1: Represents the weighted average sales price per share. These shares were sold in multiple transactions at prices ranging from $102.29 to $103.06. The Reporting Person has provided to the Issuer, and undertakes to provide to the staff of the Securities and Exchange Commission or any security holder of the Issuer, upon request, full information regarding the number of shares sold at each separate price within the range.
F10: Represents the weighted average sales price per share. These shares were sold in multiple transactions at prices ranging from $111.73 to $112.70. The Reporting Person has provided to the Issuer, and undertakes to provide to the staff of the Securities and Exchange Commission or any security holder of the Issuer, upon request, full information regarding the number of shares sold at each separate price within the range.
F11: Represents the weighted average sales price per share. These shares were sold in multiple transactions at prices ranging from $112.74 to $112.93. The Reporting Person has provided to the Issuer, and undertakes to provide to the staff of the Securities and Exchange Commission or any security holder of the Issuer, upon request, full information regarding the number of shares sold at each separate price within the range.
F2: Represents the weighted average sales price per share. These shares were sold in multiple transactions at prices ranging from $103.40 to $104.26. The Reporting Person has provided to the Issuer, and undertakes to provide to the staff of the Securities and Exchange Commission or any security holder of the Issuer, upon request, full information regarding the number of shares sold at each separate price within the range.
F3: Represents the weighted average sales price per share. These shares were sold in multiple transactions at prices ranging from $104.400 to $105.39. The Reporting Person has provided to the Issuer, and undertakes to provide to the staff of the Securities and Exchange Commission or any security holder of the Issuer, upon request, full information regarding the number of shares sold at each separate price within the range.
F4: Represents the weighted average sales price per share. These shares were sold in multiple transactions at prices ranging from $105.49 to $106.42. The Reporting Person has provided to the Issuer, and undertakes to provide to the staff of the Securities and Exchange Commission or any security holder of the Issuer, upon request, full information regarding the number of shares sold at each separate price within the range.
F5: Represents the weighted average sales price per share. These shares were sold in multiple transactions at prices ranging from $106.57 to $107.52. The Reporting Person has provided to the Issuer, and undertakes to provide to the staff of the Securities and Exchange Commission or any security holder of the Issuer, upon request, full information regarding the number of shares sold at each separate price within the range.
F6: Represents the weighted average sales price per share. These shares were sold in multiple transactions at prices ranging from $107.59 to $108.57. The Reporting Person has provided to the Issuer, and undertakes to provide to the staff of the Securities and Exchange Commission or any security holder of the Issuer, upon request, full information regarding the number of shares sold at each separate price within the range.
F7: Represents the weighted average sales price per share. These shares were sold in multiple transactions at prices ranging from $108.59 to $109.56. The Reporting Person has provided to the Issuer, and undertakes to provide to the staff of the Securities and Exchange Commission or any security holder of the Issuer, upon request, full information regarding the number of shares sold at each separate price within the range.
F8: Represents the weighted average sales price per share. These shares were sold in multiple transactions at prices ranging from $109.66 to $110.58. The Reporting Person has provided to the Issuer, and undertakes to provide to the staff of the Securities and Exchange Commission or any security holder of the Issuer, upon request, full information regarding the number of shares sold at each separate price within the range.
F9: Represents the weighted average sales price per share. These shares were sold in multiple transactions at prices ranging from $110.72 to $111.71. The Reporting Person has provided to the Issuer, and undertakes to provide to the staff of the Securities and Exchange Commission or any security holder of the Issuer, upon request, full information regarding the number of shares sold at each separate price within the range.
--- Signature ---
/s/ /s/ John G. Saia, as attorney-in-fact for AmirAli Talasaz (2026-05-22)
